Cushing’s Syndrome

Cushing's disease is a rare form of Cushing's syndrome caused by a pituitary adenoma that secretes excessive adrenocorticotropic hormone (ACTH), leading to hypercortisolism. The adenoma, typically a microadenoma, arises from the anterior pituitary and results in increased ACTH and α-MSH production, stimulating cortisol release from the adrenal glands. It most commonly affects individuals in their third and fourth decades, with an annual incidence of approximately 0.6 per million for benign adrenal adenomas contributing to the condition. Differentiation from other causes of Cushing's syndrome—such as adrenal tumors, exogenous steroid use, or ectopic ACTH production—is crucial. Oral pigmentation may occur only when the syndrome stems from Cushing disease due to elevated α-MSH. The condition remains uncommon in pediatric populations.

References:

[1]. Cushing Disease. sciencedirect.

Cushing’s Syndrome (1):

Targets:	Cytochrome P450 (1)

Cat. No.	Product Name	CAS No.	Purity	Chemical Structure

HY-B0237

Aminoglutethimide	125-84-8	98.87%
Aminoglutethimide (DL-Aminoglutethimide) is an orally active anticonvulsant with various endocrine-related side effects. Aminoglutethimide blocks multiple steroid hormone synthesis pathways by inhibiting several cytochrome P-450-dependent hydroxylases, such as aromatase, cholesterol side-chain cleavage enzyme, 11-hydroxylase, and 18-hydroxylase, with IC₅₀ values of 0.3, 3.5, 120, and 20 μM, respectively. Aminoglutethimide reduces cortisol levels. Aminoglutethimide can be used in research on Cushing's syndrome, breast cancer, and other conditions.

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