1. MAPK/ERK Pathway
  2. JNK

JNK

JNKs (c-Jun N-terminal kinases) belong to the mitogen-activated protein kinase family, and are responsive to stress stimuli, such as cytokines,ultraviolet irradiation, heat shock, and osmotic shock. JNKs play a role in T cell differentiation and the cellular apoptosis pathway. Activation occurs through a dual phosphorylation of threonine (Thr) and tyrosine (Tyr) residues within a Thr-Pro-Tyr motif located in kinase subdomain VIII. Activation is carried out by two MAP kinases, MKK4 and MKK7 and JNK can be inactivated by Ser/Thr and Tyr protein phosphatases. Downstream molecules that are activated by JNK include c-Jun, ATF2, ELK1, SMAD4, p53 and HSF1. JNKs can associate with scaffold proteins JNK interacting proteins as well as their upstream kinases JNKK1 and JNKK2 following their activation. JNK activity regulates several important cellular functions including cell growth, differentiation, survival and apoptosis.

JNK Related Products (21):

Cat. No. Product Name Effect Purity
  • HY-12041
    SP600125 Inhibitor 98.69%
    SP600125 is a broad-spectrum JNK inhibitor for JNK1, JNK2 and JNK3 with IC50 of 40 nM, 40 nM and 90 nM, respectively.
  • HY-18982
    Anisomycin Activator 98.03%
    Anisomycin is a pyrrolidine antibiotic, acts as an anti-fungal antibiotic which inhibits Protein Synthesis, also is a potent activator of SAPKs/JNKs.
  • HY-15495
    CC-930 Inhibitor 99.98%
    CC-930 is a potent JNK1/JNK2/JNK3 inhibitor with IC50 values of 61/7/6 nM, respectively, and used for the treatment of fibrotic and infammatory indications.
  • HY-13319
    JNK-IN-8 Inhibitor 99.83%
    JNK-IN-8 is a potent JNK inhibitor with IC50 of 4.7 nM, 18.7 nM, and 1 nM for JNK1, JNK2, and JNK3, respectively.
  • HY-P0069
    D-JNKI-1 Inhibitor
    D-JNKI-1 is a specific inhibitor of JNK, and strongly interferes with JNK activation.
  • HY-N3442
    Juglanin Activator
    Juglanin is a JNK activator.
  • HY-N1504
    Loureirin B Inhibitor
    Loureirin B, a flavonoid extracted from Dracaena cochinchinensis, is an inhibitor of plasminogen activator inhibitor-1 (PAI-1), with an IC50 of 26.10 μM; also inhibits KATP, the phosphorylation of ERK and JNK, and has anti-diabetic activity.
  • HY-N0176
    Dihydroartemisinin Activator >99.0%
    Dihydroartemisinin, one of the most active artemisinin derivative, exhibits anticancer activity in a number of human cancer cells.
  • HY-N2149
    Tomatidine Inhibitor >98.0%
    Tomatidine acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling.
  • HY-15617
    JNK-IN-7 Inhibitor 98.39%
    JNK-IN-7 is a potent JNK inhibitor with IC50 of 1.5, 2 and 0.7 nM for JNK1, JNK2 and JNK3, respectively.
  • HY-N0431
    Astragaloside IV Inhibitor 99.15%
    Astragaloside IV, an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cells.
  • HY-11010
    AS601245 Inhibitor 99.67%
    AS601245 is an inhibitor of the c-Jun NH2-terminal kinase (JNK) (hJNK1: IC50=150nM, hJNK2: IC50=220nM and hJNK3: IC50=70 nM), has neuroprotective properties.
  • HY-14761
    AS 602801 Inhibitor
    AS 602801 is an ATP-competitive JNK inhibitor with IC50 of 80 nM, 90 nM, and 230 nM for JNK1, JNK2, and JNK3, respectively.
  • HY-15027
    5-Aminosalicylic acid Inhibitor >98.0%
    5-Aminosalicylic acid is an anti-inflammatory compound.
  • HY-15737
    DB07268 Inhibitor 98.44%
    DB07268 is a potent and selective JNK1 inhibitor with an IC50 value of 9 nM.
  • HY-13022
    CC-401 hydrochloride Inhibitor 99.45%
    CC-401 hydrochloride is a potent inhibitor of all three forms of JNK with Ki of 25 to 50 nM.
  • HY-10366
    BI-78D3 Inhibitor 99.69%
    BI 78D3 is a competitive c-Jun N-terminal kinase (JNK) inhibitor with IC50 of 280 nM that displays > 100 fold selectivity over p38α and no activity at mTOR and PI-3K.
  • HY-12829
    SR-3306 Inhibitor
    SR-3306 is a brain penetrant small molecule JNK inhibitor from the aminopyrimidine class.
  • HY-13022A
    CC-401 Inhibitor
    CC-401 is a potent inhibitor of all three forms of JNK with Ki of 25 to 50 nM.
  • HY-15881
    TCS JNK 5a Inhibitor 98.91%
    TCS JNK 5a(JNK Inhibitor IX) is a selective inhibitor of JNK2 and JNK3 (pIC50 values are 6.7, 6.5, <5.0 and <4.8 for JNK3, JNK2, JNK1 and p38α respectively); displays no significant activity at a range of other protein kinases including EGFR, ErbB2, cdk2,