1. Anti-infection
    MAPK/ERK Pathway
  2. Bacterial
    JNK

Anisomycin (Synonyms: Flagecidin; Wuningmeisu C)

Cat. No.: HY-18982 Purity: 98.03%
Data Sheet SDS Handling Instructions

Anisomycin is a pyrrolidine antibiotic, acts as an anti-fungal antibiotic which inhibits Protein Synthesis, also is a potent activator of SAPKs/JNKs.

For research use only. We do not sell to patients.
Anisomycin Chemical Structure

Anisomycin Chemical Structure

CAS No. : 22862-76-6

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO $55 In-stock
10 mg $50 In-stock
50 mg $100 In-stock
100 mg $150 In-stock
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Customer Review

    Anisomycin purchased from MCE. Usage Cited in: Chem Biol Interact. 2017 Nov 1;277:62-73.

    Effects of silencing p53 on colistin-induced ROS production and p-JNK expression level in PC-12 cells. The protein levels of p53. The protein levels of p-JNK by western blot.
    • Biological Activity

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    • Technical Information

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    • References

    Description

    Anisomycin is a pyrrolidine antibiotic, acts as an anti-fungal antibiotic which inhibits Protein Synthesis, also is a potent activator of SAPKs/JNKs. Target: antibiotic in vitro: Anisomycin inhibits EAC cell proliferation in concentration-dependent manner. [2] Anisomycin (3 μM) decreases protein synthesis in MDA16 and MDA-MB-468 cells, and reduces colony formation by MDA-MB-468 cells. Anisomycin causes an increase in the number of apoptotic cells in MDA-MB-468 cultures, but not in MDA16 cultures. Anisomycin actives JNK phosphorylation in MDA-MB-468 cells.[3] in vivo: Peritumoral administration of anisomycin (5 mg/kg) significantly suppresses Ehrlich ascites carcinoma (EAC) growth resulting in the survival of approximately 60% of the mice 90 days after EAC inoculation. [2]

    References
    Molecular Weight

    265.31

    Formula

    C₁₄H₁₉NO₄

    CAS No.

    22862-76-6

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Shipping

    Room temperature in continental US; may vary elsewhere

    Solvent & Solubility

    10 mM in DMSO

    * "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

    Purity: 98.03%

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    Product Name:
    Anisomycin
    Cat. No.:
    HY-18982
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