1. Cell Cycle/DNA Damage
  2. CDK

CDK

CDKs (Cyclin-dependent kinases) are serine-threonine kinases first discovered for their role in regulating the cell cycle. They are also involved in regulating transcription, mRNA processing, and the differentiation of nerve cells. CDKs are relatively small proteins, with molecular weights ranging from 34 to 40 kDa, and contain little more than the kinase domain. In fact, yeast cells can proliferate normally when their CDK gene has been replaced with the homologous human gene. By definition, a CDK binds a regulatory protein called a cyclin. Without cyclin, CDK has little kinase activity; only the cyclin-CDK complex is an active kinase.
There are around 20 Cyclin-dependent kinases (CDK1-20) known till date. CDK1, 4 and 5 are involved in cell cycle, and CDK 7, 8, 9 and 11 are associated with transcription.
CDK levels remain relatively constant throughout the cell cycle and most regulation is post-translational. Most knowledge of CDK structure and function is based on CDKs of S. pombe (Cdc2), S. cerevisia (CDC28), and vertebrates (CDC2 and CDK2). The four major mechanisms of CDK regulation are cyclin binding, CAK phosphorylation, regulatory inhibitory phosphorylation, and binding of CDK inhibitory subunits (CKIs).

CDK Related Products (72):

Cat. No. Product Name Effect Purity
  • HY-16297
    LY2835219 Inhibitor 99.87%
    LY2835219 a selective CDK4/6 inhibitor with IC50 values of 2 nM and 10 nM for CDK4 and CDK6, respectively.
  • HY-50767
    Palbociclib Inhibitor 99.94%
    Palbociclib is a highly specific inhibitor of Cdk4 (IC50=11 nM) and Cdk6 (IC50=16 nM), having no activity against a panel of 36 additional protein kinases.
  • HY-50767A
    Palbociclib hydrochloride Inhibitor 99.94%
    Palbociclib hydrochloride is a highly specific inhibitor of Cdk4 (IC50=11 nM) and Cdk6 (IC50=16 nM), having no activity against a panel of 36 additional protein kinases.
  • HY-80013
    THZ1 Inhibitor 98.82%
    THZ1 is a selective and potent covalent CDK7 inhibitor with IC50 of 3.2 nM.
  • HY-10492
    Dinaciclib Inhibitor 99.10%
    Dinaciclib is a potent and selective inhibitor of CDKs, with IC50s of 1, 1, 3, and 4 nM for CDK2, CDK5, CDK1, and CDK9 activity, respectively.
  • HY-101212
    CYC065 Inhibitor 98.58%
    CYC065 is a second-generation, orally available ATP-competitive inhibitor of CDK2/CDK 9 kinases.
  • HY-101611
    MSC2530818 Inhibitor 99.59%
    MSC2530818 is a potent, selective and orally available CDK8 inhibitor with an IC50 of 2.6 nM for CDK8.
  • HY-15681
    Senexin A Inhibitor 99.93%
    Senexin A is a CDK8 inhibitor with an IC50 of 280 nM.
  • HY-15777
    LEE011 Inhibitor 99.82%
    LEE011 is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex.
  • HY-80013A
    THZ1 Hydrochloride Inhibitor 98.70%
    THZ1 Hydrochloride is a selective and potent covalent CDK7 inhibitor with IC50 of 3.2 nM.
  • HY-A0065
    Palbociclib isethionate Inhibitor 99.99%
    Palbociclib (isethionate) is a highly selective inhibitor of CDK4/6 with IC50s of 11 nM/16 nM, and shows no activity against CDK1/2/5, EGFR, FGFR, PDGFR, InsR, etc.
  • HY-30237
    Roscovitine Inhibitor 99.77%
    Roscovitine is a potent and selective CDK inhibitor with IC50 of 0.2 μM, 0.65 μM, and 0.7 μM for CDK5, Cdc2, and CDK2, respectively.
  • HY-12529
    Ro-3306 Inhibitor
    Ro-3306 is a potent and selective inhibitor of CDK1, with Kis of 20 nM, 35 nM and 340 nM for CDK1, CDK1/cyclin B1 and CDK2/cyclin E, respectively.
  • HY-10005
    Flavopiridol Inhibitor 99.11%
    Flavopiridol is a broad inhibitor of CDK, competing with ATP to inhibit CDKs including CDK1, CDK2, CDK4 with IC50s of 30, 170, 100 nM, respectively.
  • HY-12280
    THZ2 Inhibitor 99.74%
    THZ2 is a potent and selective CDK7 inhibitor with IC50 of 13.9 nM.
  • HY-10580
    BIO Inhibitor 98.37%
    BIO is a potent and selective inhibitor of GSK-3 and CDK1-cyclinB complex with IC50s of 5 nM/320 nM/80 nM for GSK-3αβ/CDK1/CDK5, respectively.
  • HY-13942
    1-NM-PP1 Inhibitor 98.83%
    1NM-PP1(PP1 Analog II) is a cell-permeable PP1 analog that acts as a potent and selective inhibitor of mutant kinases over their wild-type progenitors(IC50=28 uM vSrc; 4.2 nM v-Src-as1 I338G).
  • HY-19988
    THZ1-R Inhibitor 98.30%
    THZ1-R is an inhibitor of CDK7, with an IC50 of 146 nM.
  • HY-10012
    AZD-5438 Inhibitor 99.84%
    AZD-5438 is a potent inhibitor of CDK1/2/9 with IC50 of 16 nM/6 nM/20 nM in cell-free assays.
  • HY-13266
    BS-181 Inhibitor 99.72%
    BS-181 is a highly selective CDK7 inhibitor with IC50 of 21 nM, and > 40-fold selective for CDK7 than CDK1, 2, 4, 5, 6, or 9.