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Ribociclib

(Synonyms: LEE011)
84 Cited Publications
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Based on 84 publication(s) in Google Scholar

RRibociclib (LEE011) is an ATP-competitive and orally active CDK4/6 inhibitor that crosses the blood-brain barrier with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex.

For research use only. We do not sell to patients.

  • Purity: 99.94%
  • CAS No.: 1211441-98-3
  • Formula: C23H30N8O
  • Molecular Weight:434.54
  • Storage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 1 year , -20°C, 6 months
  • Ribociclib Chemical Structure
    Ribociclib Chemical Structure
  • Experimental Validation Results for Ribociclib
  • Experimental Validation Results for Ribociclib
  • Experimental Validation Results for Ribociclib
  • Experimental Validation Results for Ribociclib
  • Experimental Validation Results for Ribociclib
  • Experimental Validation Results for Ribociclib
  • Experimental Validation Results for Ribociclib
CAS No.: 1211441-98-3
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Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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  • Ribociclib Chemical Structure
    Ribociclib Chemical Structure
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    Ribociclib purchased from MedChemExpress. Usage Cited in: Nat Commun. 2021 Sep 10;12(1):5386. [Abstract]

    Customer Validation
     D4476 (150  mg/kg; i.g.; daily). Combination of D4476 with Ribociclib (100  mg/kg; i.g.; daily) retards MDA-MB-231 tumor growth in vivo.

  • 1/16

    Ribociclib purchased from MedChemExpress. Usage Cited in: Nat Commun. 2021 Aug 25;12(1):5112. [Abstract]

    Customer Validation
     MPF-R and TPF-R cells were treated with different concentrations of the CDK4/6 inhibitor (CDK4/6i) Palbociclib (HY-A0065), Ribociclib (HY-15777C) or Abemaciclib (HY-16297A) for 6 days. Cell growth was measured by crystal violet colorimetric assay. Growth relative to vehicle (%) is plotted against log drug concentration.

  • 1/16

    Ribociclib purchased from MedChemExpress. Usage Cited in: Eur J Cancer. 2018 Oct:102:10-22. [Abstract]

    Customer Validation
     Head-to-head comparison of the effect of PD 0332991 and Ribociclib on DNA damage response (DDR) signalling in liver cancer cells.

  • 1/16

    Ribociclib purchased from MedChemExpress. Usage Cited in: Mol Oncol. 2017 Aug;11(8):1035-1049. [Abstract]

    Customer Validation
     Effects of CDK4/6 inhibitors on AMPK phosphorylation and apoptosis-related signals. After 24 h of drug treatment, the cells are subjected to western blot analysis. AMPK phosphorylation level is quantified by the ratio of band intensities of phospho-AMPKα vs. AMPKα.

  • 1/16

    Ribociclib purchased from MedChemExpress. Usage Cited in: Mol Oncol. 2017 Aug;11(8):1035-1049. [Abstract]

    Customer Validation
     Ribociclib induces cell death in Hep3B cells. Cells are exposed to Ribociclib at 25 μM for 72 h.

  • 1/16

    Ribociclib purchased from MedChemExpress. Usage Cited in: Clin Cancer Res. 2015 Nov 1;21(21):4947-59. [Abstract]

    Customer Validation
     Retinoblastoma (RB) phosphorylation and FOXM1, another CDK4 target, are reduced in cells treated with LEE011.

  • 1/16

    Ribociclib purchased from MedChemExpress. Usage Cited in: Clin Cancer Res. 2015 Nov 1;21(21):4947-59. [Abstract]

    Customer Validation
     Retinoblastoma (RB) phosphorylation and FOXM1, another CDK4 target, are reduced in cells treated with LEE011.

  • Ribociclib