Signaling Pathway

HSV

HSV

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Herpes simplex virus (HSV-1 and HSV-2) are two members of the herpesvirus family, Herpesviridae, that infect humans. Both HSV-1 (which produces most cold sores) and HSV-2 (which produces most genital herpes) are ubiquitous and contagious. They can be spread when an infected person is producing and shedding the virus. Herpes simplex can be spread through contact with saliva, such as sharing drinks. Symptoms of herpes simplex virus infection include watery blisters in the skin or mucous membranes of the mouth, lips or genitals. Lesions heal with ascab characteristic of herpetic disease. As neurotropic and neuroinvasive viruses, HSV-1 and -2 persist in the body by becoming latent and hiding from the immune system in the cell bodies of neurons. After the initial or primary infection, some infected people experience sporadic episodes of viral reactivation or outbreaks.

HSV Inhibitors & Modulators (11)

Product Name Catalog No. Brief Description
1-Docosanol

HY-B0222

1-Docosanol is a saturated fatty alcohol used traditionally as an emollient, emulsifier, and thickener in cosmetics, and nutritional supplement; inhibitor of lipid-enveloped viruses including herpes simplex.

Acyclovir

HY-17422

Acyclovir, a molecule tailored to inactivate the thymidine kinase of the herpesvirus, is a guanosine analogue antiviral drug.

BAY 57-1293

HY-15303

BAY 57-1293 represents a new class of potent inhibitors of herpes simplex virus (HSV) that target the virus helicase primase complex.

Famciclovir

HY-17426

Famciclovir(BRL 42810) is a guanine analogue antiviral drug used for the treatment of various herpesvirus infections.

Fiacitabine

HY-50735

Fiacitabine(NSC 382097; FIAC; FOAC) is a selective inhibitior of DNA replication of herpes simplex virus(HSV) with IC50 values of 2.5 nM and 12.6 nM for HSV1 and HSV2, respectively.

Ganciclovir

HY-13637

Ganciclovir is an antiviral drug for feline herpesvirus type-1 with IC50 of 5.2 μM.

Idoxuridine

HY-B0307

Idoxuridine is an antiviral agent for feline herpesvirus type-1 with IC50 of 4.3 μM.

Penciclovir

HY-17424

Penciclovir, a novel acyclic nucleoside analogue, has demonstrated efficacy against HSV types 1 and 2 and seems to have a pharmacological advantage due to a prolonged half-life of its active form in HSV-infected cells.

Valacyclovir

HY-17425

Valacyclovir is an antiviral drug used in the management of herpes simplex, herpes zoster, and herpes B.

Valacyclovir hydrochloride

HY-17425A

Valacyclovir hydrochloride is an antiviral drug used in the management of herpes simplex, herpes zoster, and herpes B.

Vidarabine

HY-B0277

Vidarabine is an antiviral drug which is active against herpes simplex and varicella zoster viruses.