1. Anti-infection
    Autophagy
  2. Parasite
    HIV
    Mitophagy
    HSV
    SARS-CoV
    Antibiotic
    Autophagy
  3. Ivermectin

Ivermectin (Synonyms: MK-933)

Cat. No.: HY-15310 Purity: >98.0%
Handling Instructions

Ivermectin (MK-933) is a broad-spectrum anti-parasite agent. Ivermectin (MK-933) is a specific inhibitor of Impα/β1-mediated nuclear import and has potent antiviral activity towards both HIV-1 and dengue virus. It is a positive allosteric effector of P2X4 and the α7 neuronal nicotinic acetylcholine receptor (nAChRs). Ivermectin also inhibits bovine herpesvirus1 (BoHV-1) replication and inhibits BoHV-1 DNA polymerase nuclear import. Ivermectin is a candidate therapeutic against SARS-CoV-2/COVID-19.

For research use only. We do not sell to patients.

Ivermectin Chemical Structure

Ivermectin Chemical Structure

CAS No. : 70288-86-7

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Customer Review

Based on 2 publication(s) in Google Scholar

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Description

Ivermectin (MK-933) is a broad-spectrum anti-parasite agent. Ivermectin (MK-933) is a specific inhibitor of Impα/β1-mediated nuclear import and has potent antiviral activity towards both HIV-1 and dengue virus. It is a positive allosteric effector of P2X4 and the α7 neuronal nicotinic acetylcholine receptor (nAChRs). Ivermectin also inhibits bovine herpesvirus1 (BoHV-1) replication and inhibits BoHV-1 DNA polymerase nuclear import[1][2][3][4]. Ivermectin is a candidate therapeutic against SARS-CoV-2/COVID-19[5].

IC50 & Target[1]

Parasite

 

HSV-1

 

BoHV-1

 

SARS-CoV-2

 

In Vitro

In the submicromolar range (EC50=250 nM) the action of Ivermectin (MK-933) is rapid and reversible, resulting in increased amplitude and slowed deactivation of P2X4 channel currents evoked by ATP[1].
Ivermectin (MK-933) markedly increases the potency of ATP and that of the normally low-potency agonist a,b-methylene-ATP in a use- and voltage-independent manner without changing the ion selectivity of P2X4 channels[1].
Ivermectin (MK-933) activates glutamate-gated chloride channels in the nerves and muscles of the parasite, leading to membrane hyperpolarization and muscle paralysis[2].
Ivermectin (MK-933) strongly inhibits the binding of Impα/β1 to NS5 (IC50=17 μM), but not of Impβ1 alone to NS5[3].
Ivermectin (MK-933) has potent antiviral activity towards both HIV-1 and dengue virus, both of which are strongly reliant on importin α/β nuclear import, with respect to the HIV-1 integrase and NS5 (non-structural protein 5) polymerase proteins respectively[3].

Clinical Trial
Molecular Weight

875.09

Formula

C₄₈H₇₄O₁₄

CAS No.

70288-86-7

SMILES

CO[[email protected]]1C[[email protected]](O[[email protected]]2[[email protected]](C)O[[email protected]@H](O[[email protected]](/C(C)=C/C[[email protected]@H]3C[[email protected]]4C[[email protected]@]5(O[[email protected]]([H])(C(C)C)[[email protected]@H](C)CC5)O3)[[email protected]@H](C)/C=C/C=C6CO[[email protected]@]7([H])[[email protected]]\6(O)[[email protected]](C(O4)=O)C=C(C)[[email protected]]7O)C[[email protected]@H]2OC)O[[email protected]@H](C)[[email protected]@H]1O.CO[[email protected]]8C[[email protected]](O[[email protected]]9[[email protected]](C)O[[email protected]@H](O[[email protected]](/C(C)=C/C[[email protected]@H]%10C[[email protected]]%11C[[email protected]@]%12(O[[email protected]]([H])([[email protected]@H](C)CC)[[email protected]@H](C)CC%12)O%10)[[email protected]@H](C)/C=C/C=C%13CO[[email protected]@]%14([H])[[email protected]]\%13(O)[[email protected]](C(O%11)=O)C=C(C)[[email protected]]%14O)C[[email protected]@H]9OC)O[[email protected]@H](C)[[email protected]@H]8O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (57.14 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1427 mL 5.7137 mL 11.4274 mL
5 mM 0.2285 mL 1.1427 mL 2.2855 mL
10 mM 0.1143 mL 0.5714 mL 1.1427 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (2.86 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (2.86 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: >98.0%

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Keywords:

IvermectinMK-933MK933MK 933ParasiteHIVMitophagyHSVSARS-CoVAntibioticAutophagyHuman immunodeficiency virusMitochondrial AutophagyHerpes simplex virusSARS coronavirusInhibitorinhibitorinhibit

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