1. Signaling Pathways
  2. Anti-infection
  3. Parasite
  4. Trypanosoma Isoform


Trypanosoma cruzi is a protozoan parasite transmitted by hematophagic triatomine insects (kissing bugs, reduviid bugs). Triatomine insects are the exclusive insect vectors for T. cruzi. .During a blood meal, triatomine insects defecate near the bite site, and due to the intense itching caused by triatomine saliva, individuals unknowingly rub the feces containing the infectious T. cruzi trypomastigotes into the bite wound, eye or nearby mucosal surfaces. The flagellated trypomastigotes invade various cells immediately inside the wound and transform into amastigotes. Intracellular amastigotes divide rapidly by binary fission, filling the cell and transforming back to trypomastigotes, rupturing the host cell in the process. Trypomastigotes disseminate through the bloodstream and can infect almost any tissue, repeating the amastigote-to-trypomastigote cycle. Triatomine insects may become infected during ingestion of a blood meal containing circulating trypomastigotes, thus continuing the parasite life cycle.T. cruzi can also be transmitted through other routes, including vertically to the fetus, by blood transfusion and organ transplantation.

Trypanosoma Related Products (30):

Cat. No. Product Name Effect Purity
  • HY-12054
    Inhibitor ≥98.0%
    Hesperadin is an ATP competitive indolinone inhibitor of Aurora A and B.
  • HY-B0537B
    Pentamidine isethionate
    Inhibitor 99.82%
    Pentamidine isethionate (MP-601205 isethionate) is an antimicrobial agent and interferes with DNA biosynthetics.
  • HY-14989
    Inhibitor 98.24%
    SQ109 is a potent inhibitor of the trypomastigote form of the parasite, with IC50 for cell killing of 50±8 nM.
  • HY-14932
    Inhibitor 99.21%
    Pafuramidine (DB289) is an orally active prodrug of Furamidine (HY-110137A).
  • HY-B1548
    Inhibitor 99.75%
    Benznidazol (Ro 07-1051) is an antiparasitic medication, with an IC50 of 20.35 μM for Colombian T.
  • HY-B0537C
    Pentamidine dimesylate
    Pentamidine (MP-601205) dimesylate is an antimicrobial agent and interferes with DNA biosynthetics.
  • HY-146042
    Antiparasitic agent-4
    Antiparasitic agent-4 (compound 4q) has highly antiparasitic activity against Leishmania infantum (L.
  • HY-144296
    Purine phosphoribosyltransferase-IN-2
    Purine phosphoribosyltransferase-IN-2 is a potent inhibitor of the Plasmodium falciparum ((Pf)), Plasmodium vivax ((Pv)) and Trypanosoma brucei ((Tbr)) 6-oxopurine phosphoribosyltransferase (PRT), with Kis of 30, 20 and 2 nM, respectively.
  • HY-N0914
    Inhibitor 99.13%
    Ajugol is an iridoid glycoside that can be isolated from Leonurus artemisia.
  • HY-111759
    Inhibitor 98.60%
    Jaspamycin (7-CN-7-C-Ino) is a potent activator of PKA, binding to the R site (PKAR), with an EC50 of 6.5 nM and Kd of 8 nM in Trypanosoma brucei.
  • HY-N0389
    Inhibitor 99.77%
    Columbin is an orally active diterpenoid furanolactone from Calumbae radix, has anti-inflammatory and anti-trypanosomal effects.
  • HY-10836
    Inhibitor 99.90%
    Cruzain-IN-1 is a covalent and reversible Cruzain inhibitor, with an IC50 of 10 nM.
  • HY-N2590
    Inhibitor ≥98.0%
    Lupenone, isolated from Musa basjoo, belongs to lupane type triterpenoids.
  • HY-N2230
    Inhibitor 98.78%
    N-p-trans-Coumaroyltyramine is a cinnamoylphenethyl amide isolated from polygonum hyrcanicum, acts as an acetylcholinesterase (AChE) inhibitor with an an IC50 of 122 μM.
  • HY-N0397
    Inhibitor 99.72%
    Harpagide is a class of iridoid glycoside isolated from Scrophularia ningpoensis and has antiparasitic activity, which exhibits good in vitro trypanocidal activities against African trypanosomes (T.
  • HY-B0744
    Eflornithine is a specific, irreversible inhibitor of the enzyme ornithine decarboxylase.
  • HY-B0744A
    Eflornithine hydrochloride
    Eflornithine hydrochloride is a specific, irreversible inhibitor of the enzyme ornithine decarboxylase.
  • HY-120060
    GNF6702 is a selective inhibitor of the kinetoplastid proteasome.
  • HY-103033
    Inhibitor 99.21%
  • HY-B0537AS
    Pentamidine-d4 dihydrochloride
    Pentamidine-d4 (MP-601205-d4) dihydrochloride is the deuterium labeled Pentamidine dihydrochloride.