1. Anti-infection
  2. Parasite Antibiotic
  3. Pafuramidine

Pafuramidine  (Synonyms: DB289)

Cat. No.: HY-14932 Purity: 98.28%
COA Handling Instructions

Pafuramidine (DB289) is an orally active proagent of Furamidine (HY-110137A). Pafuramidine is a potent anti-parasitic agent, can be used to research trypanosomiasis, Pneumocystis pneumonia and malaria.

For research use only. We do not sell to patients.

Pafuramidine Chemical Structure

Pafuramidine Chemical Structure

CAS No. : 186953-56-0

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 330 In-stock
Solution
10 mM * 1 mL in DMSO USD 330 In-stock
Solid
5 mg USD 300 In-stock
10 mg USD 456 In-stock
50 mg USD 1080 In-stock
100 mg USD 1680 In-stock
200 mg   Get quote  
500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Pafuramidine:

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Pafuramidine

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Pafuramidine (DB289) is an orally active proagent of Furamidine (HY-110137A). Pafuramidine is a potent anti-parasitic agent, can be used to research trypanosomiasis, Pneumocystis pneumonia and malaria[1][2][3].

IC50 & Target[1][3]

Trypanosoma

 

Plasmodium falciparum sporozoites

 

In Vivo

Pafuramidine (1-10 mg/kg; p.o.; for 5 or 10 days) cures some trypanosomes-infected monkeys[1].
Pafuramidine (2.5-100 mg/kg; p.o.; for 4 or 5 days) cures some Trypanosoma brucei-infected mice[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Vervet monkeys (infected by intravenous injection of 104 trypanosomes)[1]
Dosage: 1, 3, and 10 mg/kg (group 1/2/3); 10 mg/kg (group 4/5)
Administration: p.o.; 5 consecutive days for group 1/2/3 (started on the 7th day postinfection); 10 days for group 4 (started on the 14th day postinfection); 10 days for group 5 (started on the 28th day postinfection). Post-treatment monitoring was maintained for a period of 180 days.
Result: Cured all three monkeys in group 3 at 10 mg/kg, and did not recur during the monitoring period.
All three monkeys in group 4 became aparasitemic by day 5 of dosing, but only two of three monkeys remained free of blood parasites until 180 days post-treatment monitoring.
All three monkeys in group 5 became aparasitemic by day 4 of dosing, but only two of three of monkeys remained free of blood trypanosomes by the end of the 180 days of post-treatment monitoring.
Animal Model: Female NMRI mice (infected intraperitoneally with 2 × 104 STIB900 bloodstream forms)[5]
Dosage: 2.5, 5, 25 and 50 mg/kg
Administration: p.o.; for 4 days (started on the 4th day postinfection)
Result: Cured all four mice at 25 and 50 mg/kg.
Animal Model: Female NMRI mice (infected intraperitoneally with 2 × 104 GVR35 bloodstream forms)[5]
Dosage: 25, 50 and 100 mg/kg
Administration: p.o.; for 5 days (started on the 21st day postinfection)
Result: Showed good CNS activity in the GVR35 CNS model, with 3/5 mice cured at 100 mg/kg.
Clinical Trial
Molecular Weight

364.40

Formula

C20H20N4O3

CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

N=C(C1=CC=C(C2=CC=C(C3=CC=C(C(NOC)=N)C=C3)O2)C=C1)NOC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 33.33 mg/mL (91.47 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7442 mL 13.7212 mL 27.4424 mL
5 mM 0.5488 mL 2.7442 mL 5.4885 mL
10 mM 0.2744 mL 1.3721 mL 2.7442 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (6.86 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.08 mg/mL (5.71 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.08 mg/mL (5.71 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 99.21%

References
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Pafuramidine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Pafuramidine
Cat. No.:
HY-14932
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