2. Disease Areas
  3. Inflammation or Immune System Disease Respiratory Disease
  4. Pathogens Infection Respiratory Inflammation Lower Respiratory Inflammation
  5. Pneumonia

Pneumonia

Pneumonia is an inflammatory condition of the lungs, primarily affecting the alveoli, characterized by symptoms such as cough, chest pain, fever, shortness of breath, and fatigue. It can be caused by various pathogens including bacteria like Streptococcus pneumoniae and Haemophilus influenzae, viruses such as SARS-CoV-2 (COVID-19), and other microorganisms. Pleuro-pneumonia refers to a specific form involving both lung tissue and pleura, often associated with organisms resistant to chloramphenicol, rendering this antibiotic ineffective. Diagnosis typically involves identifying the causative pathogen through clinical evaluation and laboratory testing.

References:

Pneumonia (7):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-142021
    Z-Leu-Arg-AMC 156192-32-4 99.24%
    Z-Leu-Arg-AMC is a fluorogenic peptide substrate for cysteine proteases (e.g., Cathepsin) (Ex=350 nm，Em=460 nm). Z-Leu-Arg-AMC is preferentially cleaved by Cathepsin K and S under weakly acidic conditions, while its hydrolysis relies on residual Cathepsin S activity at neutral pH. Z-Leu-Arg-AMC serves as a substrate for recombinant Sphenophorus levis Cathepsin L, falcipain-2, falcipain-3, berghepain-2, knowlepain-2, vivapain-2, as well as falcipain-2 chimeras and constructs. It enables quantitative detection of cysteine protease activity in human inflammatory bronchoalveolar lavage fluid via fluorescence generation. Z-Leu-Arg-AMC can be used in research related to pulmonary inflammatory diseases and malaria.
    Z-Leu-Arg-AMC
  • HY-157536
    SMT-738 2862851-15-6 98.47%
    SMT-738 is a bacterial bactericide. SMT-738 targets the small molecules responsible for lipoprotein transport in Enterobacteriaceae, causing abnormal lipoprotein localization and bacterial cell death. SMT-738 inhibits the growth of E. coli and K. pneumoniae. SMT-738 reduces bacterial loads in mouse models of urinary tract infection, bloodstream infection, and pulmonary infection caused by Enterobacterales. SMT-738 can be used in the research of Enterobacteriaceae infections, urinary tract infections, bloodstream infections, and pneumonia.
    SMT-738
  • HY-P2866
    β-N-Acetylhexosaminidase, Streptococcus pneumoniae 9012-33-3
    β-N-Acetylhexosaminidase, Streptococcus pneumoniae is a cell surface virulence factor of Streptococcus pneumoniae, which contains two synergistically acting GH20 domains (with higher activity in GH20-2). β-N-Acetylhexosaminidase, Streptococcus pneumoniae specifically recognizes and hydrolyzes substrates with β(1,2) glycosidic bonds via Trp-443 and Tyr-482 residues. β-N-Acetylhexosaminidase, Streptococcus pneumoniae catalyzes the hydrolysis of β(1,2)-linked N-acetylglucosamine groups and related disaccharides, and promotes persistent colonization of bacteria in the airway by modifying host defense molecules and releasing monosaccharides for bacterial growth. β-N-Acetylhexosaminidase, Streptococcus pneumoniae can be used in studies related to Streptococcus pneumoniae infection, acute pneumonia, otitis media and meningitis.
    β-N-Acetylhexosaminidase, Streptococcus pneumoniae
  • HY-177063
    IL-6-IN-2 296790-70-0 99.95%
    IL-6-IN-2 is an interleukin-6 (IL-6) inhibitor. IL-6-IN-2 binds to IL-6 at Lys66, Phe74, Gln175, Ser176, and Arg179 via π-π, π-alkyl, hydrogen bond, and hydrophobic interactions to block IL-6/IL-6R heterocomplex formation. IL-6-IN-2 exhibits low gastrointestinal absorption rate. IL-6-IN-2 can be used for the research of cytokine release syndrome, covid-19.
    IL-6-IN-2
  • HY-124183
    SX-576 1240494-14-7
    SX-576 is a CXCR1 and CXCR2 antagonist with IC50 values of 31 nM and 21 nM, respectively. SX-576 inhibits neutrophil infiltration in a rat model of pulmonary inflammation. SX-576 can be used in studies related to pulmonary inflammation.
    SX-576
  • HY-119708A
    Ensifentrine tosylate 3098314-20-3
    Ensifentrine (RPL-554) tosylate is an inhaled dual inhibitor of PDE3 and PDE4 with IC50s of 0.4 nM and 1479 nM, respectively. Ensifentrine tosylate blocks PDE3 and PDE4 enzymes, thereby increasing the levels of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) in lung cells, dilating the bronchi, and inhibiting the activation and migration of inflammatory cells. Ensifentrine tosylate can be used in the research of chronic obstructive pulmonary disease (COPD).
    Ensifentrine tosylate
  • HY-113500A
    Hepoxilin A3 94161-11-2
    Hepoxilin A3 (HXA3) is a neutrophil chemo-attractant, synthesized by activating the PLA2-12-LOX pathway. Hepoxilin A3 can guide neutrophils to cross the epithelial barrier and migrate to the infection site (such as the alveolar cavity). The level of Hepoxilin A3 increases synchronously with neutrophil infiltration in mouse models. Hepoxilin A3 can be used to study inflammatory diseases (such as pneumonia, cystic fibrosis).
    Hepoxilin A3