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  4. Z-Leu-Arg-AMC

Z-Leu-Arg-AMC is a 4-methylcoumarinyl-7-amide (Amc) leucine derivative with carboxybenzoyl (Z). Z-Leu-Arg-AMC is the active site of cysteine proteinase trypanopain-Tb from Trypanosoma brucei brucei.

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Z-Leu-Arg-AMC Chemical Structure

Z-Leu-Arg-AMC Chemical Structure

CAS No. : 156192-32-4

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5 mg USD 212 In-stock
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Based on 1 publication(s) in Google Scholar

Z-Leu-Arg-AMC Related Antibodies

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Description

Z-Leu-Arg-AMC is a 4-methylcoumarinyl-7-amide (Amc) leucine derivative with carboxybenzoyl (Z). Z-Leu-Arg-AMC is the active site of cysteine proteinase trypanopain-Tb from Trypanosoma brucei brucei[1].

IC50 & Target

Trypanosoma

 

Molecular Weight

578.66

Formula

C30H38N6O6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC(C1=CC=C(NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC(OCC2=CC=CC=C2)=O)=O)=O)C=C1O3)=CC3=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (172.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7281 mL 8.6407 mL 17.2813 mL
5 mM 0.3456 mL 1.7281 mL 3.4563 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7281 mL 8.6407 mL 17.2813 mL 43.2033 mL
5 mM 0.3456 mL 1.7281 mL 3.4563 mL 8.6407 mL
10 mM 0.1728 mL 0.8641 mL 1.7281 mL 4.3203 mL
15 mM 0.1152 mL 0.5760 mL 1.1521 mL 2.8802 mL
20 mM 0.0864 mL 0.4320 mL 0.8641 mL 2.1602 mL
25 mM 0.0691 mL 0.3456 mL 0.6913 mL 1.7281 mL
30 mM 0.0576 mL 0.2880 mL 0.5760 mL 1.4401 mL
40 mM 0.0432 mL 0.2160 mL 0.4320 mL 1.0801 mL
50 mM 0.0346 mL 0.1728 mL 0.3456 mL 0.8641 mL
60 mM 0.0288 mL 0.1440 mL 0.2880 mL 0.7201 mL
80 mM 0.0216 mL 0.1080 mL 0.2160 mL 0.5400 mL
100 mM 0.0173 mL 0.0864 mL 0.1728 mL 0.4320 mL
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Z-Leu-Arg-AMC Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Z-Leu-Arg-AMC156192-32-4ParasiteInhibitorinhibitorinhibit

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