IL-15 Receptor
IL-15 Receptor (IL-15R) is a heterotrimeric receptor which consists of IL-15Rα, IL-2Rβ and IL-2Rγc. IL-15R binds IL-15 (structurally similar to IL-2). IL-15Rα is a high affinity receptor for IL-15 (Kd: 100 pM), and IL-15R shares IL-2Rβ and IL-2Rγc subunits with IL-2R[1]. IL-15Rα can bind IL-15 and thereby activating the antitumor functions of NK cells and CD8+ T cells[2]. IL-15R alpha plays an important role in memory CD8 T cell homeostasis and lymphocyte development[1]. IL-15R alpha is also required for transporting of IL-15 from the endoplasmic reticulum to the cell surface[3].IL-15Rα is expressed on lymphocytes, myeloid cells, nonlymphoid and nonhematopoietic cells[1].
- [1]. Patrick R Burkett, et al. IL-15R alpha expression on CD8+ T cells is dispensable for T cell memory. Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4724-9. [Content Brief]
- [2]. Johan Mj Van den Bergh, et al. IL-15 receptor alpha as the magic wand to boost the success of IL-15 antitumor therapies: The upswing of IL-15 transpresentation. Pharmacol Ther. 2017 Feb;170:73-79. [Content Brief]
- [3]. Spencer W Stonier, et al. Trans-presentation: a novel mechanism regulating IL-15 delivery and responses. Immunol Lett. 2010 Jan 4;127(2):85-92. [Content Brief]
-
IL-15 Receptor Recombinant Proteins (12)
- Species:
- Source:
- Species:
- Source:
- Species:
- Source:
- Species:
- Source:
- 1
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- 1
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
