BDCA-3/CD141
BDCA-3, better known in vascular biology as thrombomodulin, is the CD141 antigen and a type I transmembrane glycoprotein of endothelial cells. By binding thrombin, thrombomodulin redirects the protease from procoagulant substrates toward activation of protein C, generating the principal anticoagulant pathway, and it additionally supports thrombin-activatable fibrinolysis inhibitor activation. In immunology, CD141 (BDCA-3) identifies the human CD141-positive dendritic cell subset that corresponds to the cross-presenting mouse CD8alpha-positive lineage, prized for antigen uptake and cytotoxic T cell priming. Soluble thrombomodulin serves as a marker of endothelial injury, and recombinant soluble thrombomodulin is used to treat disseminated intravascular coagulation.
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BDCA-3/CD141 Recombinant Proteins (4)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
