IL-27 Receptor
The interleukin-27 receptor, also designated WSX-1 or T-cell cytokine receptor (TCCR, CD130 family relative), is the private ligand-binding component of the functional IL-27 receptor complex. This type I transmembrane glycoprotein belongs to the class I cytokine receptor superfamily and pairs with gp130 (IL-6ST) to form the complete receptor for the heterodimeric cytokine IL-27 (IL-27A/EBI3). Ligand engagement activates JAK1/TYK2 and phosphorylates STAT1 and STAT3, which mediate T-bet induction and Th1 differentiation, expansion of naive T cells, and production of CXCR3 ligands from antigen-presenting cells. WSX-1 also possesses immunoregulatory functions: it restrains Th17 and Tfh responses, limits experimental autoimmune encephalomyelitis, and suppresses chronic intestinal inflammation. WSX-1-deficient mice display enhanced cytokine storm during intracellular infection, and altered WSX-1 signaling is associated with lupus and Crohn's disease.
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IL-27 Receptor Recombinant Proteins (2)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
