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  2. Cytokines and Growth Factors
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  4. IL-27 Receptor
  5. IL27RA
  6. IL-27R alpha/TCCR Protein, Human (514a.a, HEK293, Fc)

IL-27R alpha/TCCR Protein, Human (514a.a, HEK293, Fc)

Cat. No.: HY-P77223
Handling Instructions

IL-27R alpha(Interleukin 27 receptor alpha) is a subunit of the interleukin-27 receptor, an inflammatory cytokine that possesses extensive immunological functions. IL-27R alphacan be used as a natural IL-27 antagonist. IL-27R alpha/TCCR Protein, Human (514a.a, HEK293, Fc) is a recombinant protein with a Fc label that consists of 514 amino acids (M1-R514) and is produced by HEK293 cells.

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Description

IL-27R alpha(Interleukin 27 receptor alpha) is a subunit of the interleukin-27 receptor, an inflammatory cytokine that possesses extensive immunological functions. IL-27R alphacan be used as a natural IL-27 antagonist[1]. IL-27R alpha/TCCR Protein, Human (514a.a, HEK293, Fc) is a recombinant protein with a Fc label that consists of 514 amino acids (M1-R514) and is produced by HEK293 cells.

Background

IL-27Rα is specific for IL-27 and is primarily expressed on the cell surface of inflammatory cells, including T, B, and NK lymphocytes, neutrophils, monocytes, and mast cells, although it is found at lower levels in macrophages, hepatocytes, keratinocytes, and endothelial cells[2].
The amino acid sequence of human IL-27R alpha protein has low homology for mouse IL-27R alpha protein.
IL-27Rα (WSX-1) and gp130 compose the IL-27 receptor-signaling complex. Binding of IL-27 to its heterodimeric receptor complex leads to the intracellular recruitment and activation of the Janus kinase (JAK)/STAT-1 and STAT-3 pathways, suppress the expression of inflammatory cytokines[3].
IL-27R alpha is a class I cytokine receptor with homology to gp130 of IL-6R and to IL-12R families. IL-27R alpha can be used as a natural IL-27 antagonist[1]. IL-27R alpha can be used as an independent prognostic aGVHD biomarker[4]. IL-27/IL-27R alpha also plays an important role in the down-regulation of airway hyper-reactivity and lung inflammation during the development of allergic asthma through its suppressive effect on cytokine production[5]. IL-27/IL-27RA signaling can suppress the expression of inflammatory cytokines, IL-6 and IL-8, induced by LPS stimulation, leading to phosphorylation of STAT1 and STAT3[6].

Species

Human

Source

HEK293

Tag

C-hFc

Accession

Q6UWB1 (Q33-R514)

Gene ID
Molecular Construction
N-term
IL-27Rα (Q33-R514)
Accession # Q6UWB1
hFc
C-term
Synonyms
Interleukin-27 receptor subunit alpha; IL-27R-alpha; TCCR; WSX-1; IL-27RA
Molecular Weight

105-115 kDa

Purity

Greater than 95% as determined by reducing SDS-PAGE

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation
References

IL-27R alpha/TCCR Protein, Human (514a.a, HEK293, Fc) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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IL-27R alpha/TCCR Protein, Human (514a.a, HEK293, Fc)
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HY-P77223
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