2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. Interleukin & Receptors
  5. IL-27 Receptor
  6. IL27RA

IL27RA

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IL-27R alpha (Interleukin 27 receptor alpha) is a subunit of the interleukin-27 receptor, an inflammatory cytokine that possesses extensive immunological functions[1]. IL-27Rα is specific for IL-27 and is primarily expressed on the cell surface of inflammatory cells, including T, B, and NK lymphocytes, neutrophils, monocytes, and mast cells, although it is found at lower levels in macrophages, hepatocytes, keratinocytes, and endothelial cells. IL-27R alpha can be used as a natural IL-27 antagonist[1].IL-27Rα (WSX-1) and gp130 compose the IL-27 receptor-signaling complex. Binding of IL-27 to its heterodimeric receptor complex leads to the intracellular recruitment and activation of the Janus kinase (JAK)/STAT-1 and STAT-3 pathways, suppress the expression of inflammatory cytokines. IL-27R alpha can be used as a natural IL-27 antagonist[1]. IL-27R alpha can be used as an independent prognostic aGVHD biomarker[2]. IL-27/IL-27RA signaling can suppress the expression of inflammatory cytokines, IL-6 and IL-8, induced by LPS stimulation, leads to phosphorylation of STAT1 and STAT3[3].

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Cat. No. Product Name / Synonyms Species Source
  • HY-P76668
    IL-27R alpha/TCCR Protein, Mouse (HEK293, His)

    Interleukin-27 receptor subunit alpha; IL-27R-alpha; TCCR; WSX-1; IL-27RA

    		Mouse HEK293
    IL-27R alpha(Interleukin 27 receptor alpha) is a subunit of the interleukin-27 receptor, an inflammatory cytokine that possesses extensive immunological functions. IL-27R alphacan be used as a natural IL-27 antagonist. IL-27R alpha/TCCR Protein, Mouse (HEK293, His) is a recombinant protein with a His label that consists of 482 amino acids (G29-K510) and is produced by HEK293 cells.
  • HY-P701013
    IL-27R alpha/TCCR Protein, Human (HEK293, His)

    IL-27RA; TCCR; IL27RA; IL-27R-alpha; IL27R alpha; WSX-1; WSX1; ZcytoR1; CRL1; IL-27 RA; IL27 RA

    		Human HEK293
    IL-27R alpha/TCCR Protein, acting as a receptor for IL27, relies on IL6ST/GP130 for signal transduction, activating STAT3 and STAT1. It is also part of a complex with IL6ST/GP130 and CNTFR, functioning as a receptor for the neuroprotective peptide humanin. IL-27R alpha/TCCR is implicated in regulating Th1-type immune responses and participating in innate defense mechanisms. This receptor is a key component of a complex with IL6ST/GP130, IL27RA/WSX1, and CNTFR, interacting with the neuroprotective peptide humanin. IL-27R alpha/TCCR Protein, Human (HEK293, His) is the recombinant human-derived IL-27R alpha/TCCR protein, expressed by HEK293, with C-His labeled tag. The total length of IL-27R alpha/TCCR Protein, Human (HEK293, His) is 483 a.a., with molecular weight of 75-105 kDa.
  • HY-P77223
    IL-27R alpha/TCCR Protein, Human (514a.a, HEK293, Fc)

    Interleukin-27 receptor subunit alpha; IL-27R-alpha; TCCR; WSX-1; IL-27RA

    		Human HEK293
    IL-27R alpha(Interleukin 27 receptor alpha) is a subunit of the interleukin-27 receptor, an inflammatory cytokine that possesses extensive immunological functions. IL-27R alphacan be used as a natural IL-27 antagonist. IL-27R alpha/TCCR Protein, Human (514a.a, HEK293, Fc) is a recombinant protein with a Fc label that consists of 514 amino acids (M1-R514) and is produced by HEK293 cells.
Cat. No. Product Name Effect Purity