IL-1 Rrp2
Interleukin-1 receptor-related protein 2 (IL-1Rrp2, officially IL-1RL2 and better known as IL-36R or IL-1R6) is the specific receptor subunit for the IL-36 subfamily of IL-1 family cytokines, comprising IL-36α, IL-36β, IL-36γ and the antagonist IL-36RA. It is a type I transmembrane protein with three extracellular Ig-like domains and a cytoplasmic Toll/IL-1 receptor (TIR) domain. Upon binding an agonistic IL-36 ligand, IL-1RL2 recruits IL-1RAcP, and the complex engages MyD88, IRAK, TRAF6 and downstream NF-κB and MAPK cascades. IL-1RL2 is prominently expressed by keratinocytes, and also by monocytes, dendritic cells and epithelial barriers. This pathway drives psoriasis and other neutrophil-rich sterile inflammations: IL-1RL2 activation induces CXCL1, CXCL8, IL-6 and IL-23 production, linking barrier epithelium to IL-17/IL-23 axis amplification. Monoclonal antibodies blocking IL-1RL2 (e.g., ANB020) are under clinical evaluation for generalized pustular psoriasis and inflammatory bowel disease.
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IL-1 Rrp2 Recombinant Proteins (7)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
