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  5. IL-1RL2 Protein, Human (HEK293, His-Avi)

IL-1RL2 Protein, Human (HEK293, His-Avi)

Cat. No.: HY-P78462
Handling Instructions

IL-1RL2 Protein, serving as a receptor for interleukin-36 (IL36A, IL36B, and IL36G), forms a complex with the coreceptor IL1RAP, constituting the interleukin-36 receptor. This complex activates NF-kappa-B, MAPK, and other pathways, resembling the IL-1 system. IL-1RL2 is implicated in local inflammatory responses at epithelial barriers, particularly contributing to skin inflammatory reactions by inducing the IL-23/IL-17/IL-22 pathway. IL-1RL2 Protein, Human (HEK293, His-Avi) is the recombinant human-derived IL-1RL2 protein, expressed by HEK293, with C-Avi, C-His labeled tag. The total length of IL-1RL2 Protein, Human (HEK293, His-Avi) is 316 a.a., with molecular weight of 60-70 kDa.

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Description

IL-1RL2 Protein, serving as a receptor for interleukin-36 (IL36A, IL36B, and IL36G), forms a complex with the coreceptor IL1RAP, constituting the interleukin-36 receptor. This complex activates NF-kappa-B, MAPK, and other pathways, resembling the IL-1 system. IL-1RL2 is implicated in local inflammatory responses at epithelial barriers, particularly contributing to skin inflammatory reactions by inducing the IL-23/IL-17/IL-22 pathway. IL-1RL2 Protein, Human (HEK293, His-Avi) is the recombinant human-derived IL-1RL2 protein, expressed by HEK293, with C-Avi, C-His labeled tag. The total length of IL-1RL2 Protein, Human (HEK293, His-Avi) is 316 a.a., with molecular weight of 60-70 kDa.

Background

IL-1RL2, a receptor for interleukin-36 (IL36A, IL36B, and IL36G), engages in complex signaling events upon binding to interleukin-36. Through association with the coreceptor IL1RAP, the interleukin-36 receptor complex is formed, orchestrating interleukin-36-dependent activation of NF-kappa-B, MAPK, and other pathways. This signaling system, akin to the IL-1 system, is implicated in local inflammatory responses within epithelial barriers, particularly contributing to skin inflammatory reactions by inducing the IL-23/IL-17/IL-22 pathway.

Species

Human

Source

HEK293

Tag

C-Avi;C-His

Accession

Q9HB29 (D20-R335)

Gene ID
Molecular Construction
N-term
IL-1RL2 (D20-R335)
Accession # Q9HB29
His-Avi
C-term
Synonyms
IL-1 R6; IL-1 Rrp2; IL1RL2; IL1Rrp2; IL1RRP2; IL-36R
Molecular Weight

60-70 kDa

Purity

Greater than 95% as determined by Tris-Bis PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

IL-1RL2 Protein, Human (HEK293, His-Avi) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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IL-1RL2 Protein, Human (HEK293, His-Avi)
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HY-P78462
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