MCAM/CD146
MCAM, the CD146 antigen, is a cell adhesion molecule of the immunoglobulin superfamily carrying five extracellular Ig-like domains. It was originally characterized on melanoma cells as a promoter of metastatic spread, and it is also expressed on melanocytes and perivascular mural cells. On endothelium MCAM localizes to intercellular junctions, where it participates in barrier organization and permeability control, and it marks the pericyte-containing fraction of stromal vascular cells. The antigen contributes to angiogenesis and vascular stability, and its expression patterns have made it a subject of interest in tumor progression, endothelial biology and mesenchymal stromal cell characterization.
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MCAM/CD146 Recombinant Proteins (4)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
