2. Recombinant Proteins
  3. Receptor Proteins
  4. Pattern Recognition Receptors
  5. C-type Lectin Receptors

C-type Lectin Receptors

Recombinant Protein Expression Service

C-type Lectin Receptors

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C-type lectin receptors (CLRs) are a large family of transmembrane pattern recognition receptors (PRRs) involved in recognition and induction of adaptive immune responses to pathogens. CLRs comprise a large family of receptors which bind carbohydrates. They are characterized by one or more C-type lectin-like domains (CTLDs) and classified into 17 groups based on features including phylogeny and structure. CLRs are prominently expressed on myeloid cells. Based on their intracellular signaling motifs, CLRs can be further subdivided into: 1) Activation spleen tyrosine kinase (Syk)-coupled CLRs with immunoreceptor tyrosine-based activating motif (ITAM) or hemITAM, such as Mincle, Dectin-1 and Dectin-2; 2) Inhibitory CLRs with immunoreceptor tyrosine-based inhibition motif (ITIM) domains, such as DCIR; 3) A group of CLRs lacking typical signaling motifs, such as Mannose receptor, DEC-205 and DC-SIGN. Upon ligand binding, CLRs stimulate intracellular signaling cascades that induce the production of inflammatory cytokines and chemokines, consequently triggering innate and adaptive immunity to pathogens.

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Cat. No. Product Name / Synonyms Species Source
  • HY-P78085
    CD161 Protein, Human (Biotinylated, HEK293, His-Avi)

    KLRB1; CLEC5B; NKRP1A; NKR-P1A; HNKR-P1a; CD161; Ly59; NKR; NKRP1; NKR-P1; NKRP1ANKR

    		Human HEK293
    CD161 protein plays a crucial role in inhibiting NK cell toxicity by activating specific acid sphingomyelinase/SMPD1 and increasing ceramide levels. Activation stimulates AKT1/PKB and RPS6KA1/RSK1 kinases, enhancing anti-CD3-induced T cell proliferation. CD161 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived CD161 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of CD161 Protein, Human (Biotinylated, HEK293, His-Avi) is 159 a.a., with molecular weight of 35-43 kDa.
  • HY-P77631
    CLEC12A/MICL Protein, Human (HEK293, Fc)

    MICL; CLL-1; CLEC12A; CLL1; DCAL2; DCAL-2; CD371; CD303; CLECSF11; CLECSF7; DLEC; HECL; PRO34150; DCAL-2

    		Human HEK293
    CLEC12A/MICL is a cell surface receptor known to regulate signaling cascades and facilitate the tyrosine phosphorylation of target MAP kinases. It interacts with PTPN6 and PTPN11, indicating its involvement in intricate cellular signaling processes. CLEC12A/MICL Protein, Human (HEK293, Fc) is the recombinant human-derived CLEC12A/MICL protein, expressed by HEK293 , with N-hFc labeled tag. The total length of CLEC12A/MICL Protein, Human (HEK293, Fc) is 201 a.a., with molecular weight of 68-73 kDa.
  • HY-P77633
    CLEC12A/MICL Protein, Human (Biotinylated, HEK293, His-Avi)

    MICL; CLL-1; CLEC12A; CLL1; DCAL2; DCAL-2; CD371; CD303; CLECSF11; CLECSF7; DLEC; HECL; PRO34150; DCAL-2

    		Human HEK293
    CLEC12A/MICL is a cell surface receptor known to regulate signaling cascades and facilitate the tyrosine phosphorylation of target MAP kinases. It interacts with PTPN6 and PTPN11, indicating its involvement in intricate cellular signaling processes. CLEC12A/MICL Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived CLEC12A/MICL protein, expressed by HEK293 , with C-Avi, N-His labeled tag. The total length of CLEC12A/MICL Protein, Human (Biotinylated, HEK293, His-Avi) is 201 a.a., with molecular weight of 40-60 kDa.
  • HY-P77904
    CLEC9A Protein, Human (HEK293, Fc)

    CD370; CLEC9A; 9830005G06Rik; DNGR-1; HEEE9341; UNQ9341

    		Human HEK293
    The CLEC9A Protein, expressed on a specific subset of myeloid cells, efficiently uptakes and processes material from deceased cells. It recognizes filamentous actin, especially with actin-binding domains like spectrin, when cell membranes are compromised. This facilitates Syk-dependent cross-presentation of antigens from dead cells. CLEC9A functions as a homodimer, highlighting its role in specialized endocytic processes of myeloid cells. CLEC9A Protein, Human (HEK293, Fc) is the recombinant human-derived CLEC9A protein, expressed by HEK293 , with N-hFc labeled tag. The total length of CLEC9A Protein, Human (HEK293, Fc) is 185 a.a., with molecular weight of 55-65 kDa.
  • HY-P70110
    DC-SIGN/CD209 Protein, Human (HEK293, Fc)

    rHuCD209 antigen/CD209, Fc; CD209 molecule; CD209; CDSIGNHIV gpl20-binding protein; CLEC4L; DCSIGN; DC-SIGN; DC-SIGN1; CD209 Antigen

    		Human HEK293
    The DC-SIGN/CD209 protein is expressed on immature dendritic cells (DC) and is an important pathogen recognition receptor that initiates primary immune responses. It mediates endocytosis and subsequent degradation of pathogens within the lysosomal compartment. DC-SIGN/CD209 Protein, Human (HEK293, Fc) is the recombinant human-derived DC-SIGN/CD209 protein, expressed by HEK293 , with N-hFc labeled tag. The total length of DC-SIGN/CD209 Protein, Human (HEK293, Fc) is 346 a.a., with molecular weight of ~78 kDa.
  • HY-P70118
    CLEC4E Protein, Human (HEK293, His)

    rHuC-Type Lectin Domain Family 4 Member E/CLEC4E, His; C-Type Lectin Domain Family 4 Member E; C-Type Lectin Superfamily Member 9; Macrophage-Inducible C-Type Lectin; CLEC4E; CLECSF9; MINCLE

    		Human HEK293
    The CLEC4E protein is a calcium-dependent lectin that functions as a pattern recognition receptor in the immune system. It detects and binds DAMPs and PAMPs, including α-mannose residues on mycobacterial TDM and fungi. CLEC4E Protein, Human (HEK293, His) is the recombinant human-derived CLEC4E protein, expressed by HEK293 , with C-6*His labeled tag. The total length of CLEC4E Protein, Human (HEK293, His) is 179 a.a., with molecular weight of ~26.0 kDa.
  • HY-P72014
    CLEC4C Protein, Human (His-SUMO)

    CLEC4C; BDCA2; CLECSF11; CLECSF7; DLEC; HECL; UNQ9361/PRO34150C-type lectin domain family 4 member C; Blood dendritic cell antigen 2; BDCA-2; C-type lectin superfamily member 7; Dendritic lectin; CD antigen CD303

    		Human E. coli
    CLEC4C is a lectin-type cell surface receptor that plays a crucial role in antigen capture by dendritic cells. It specifically recognizes non-sialylated galactose-terminated biantennary glycans with the trisaccharide epitope Gal(beta1-3/4)GlcNAc(beta1-2)Man. CLEC4C Protein, Human (His-SUMO) is the recombinant human-derived CLEC4C protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag. The total length of CLEC4C Protein, Human (His-SUMO) is 169 a.a., with molecular weight of ~36.0 kDa.
  • HY-P72689
    CLEC10A/CD301 Protein, Human (HEK293, His)

    C-type lectin domain family 10 member A; CD301; CLEC10A; CLECSF13; CLECSF14; HML

    		Human HEK293
    CLEC10A/CD301 Protein, implicated in probable immune response regulation, binds Tn-Ag sugar moieties in a calcium-dependent manner. Recognizing these structures on carcinoma cells, CLEC10A/CD301 suggests a role in immune surveillance. Further exploration of its molecular interactions and downstream signaling pathways will enhance understanding of its contributions to immune modulation, especially in the context of cancer immunity. CLEC10A/CD301 Protein, Human (HEK293, His) is the recombinant human-derived CLEC10A/CD301 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of CLEC10A/CD301 Protein, Human (HEK293, His) is 256 a.a., with molecular weight of ~40 kDa.
  • HY-P72713
    CD69 Protein, Human (HEK293, His)

    Early activation antigen CD69; AIM; MLR-3; CD69; CLEC2C

    		Human HEK293
    CD69 protein, a key player in lymphocyte proliferation, acts as a signaling receptor in lymphocytes, natural killer (NK) cells, and platelets. It forms homodimers connected by disulfide bonds, highlighting its central role in cellular signaling for immune responses and platelet function. CD69 Protein, Human (HEK293, His) is the recombinant human-derived CD69 protein, expressed by HEK293 , with N-8*His labeled tag. The total length of CD69 Protein, Human (HEK293, His) is 136 a.a., with molecular weight of 18-28 kDa.
  • HY-P72739
    CD299 Protein, Human (HEK293, His-Flag)

    C-type lectin domain family 4 member M; DC-SIGNR; DC-SIGN2; L-SIGN; CD299; CLEC4M; CD209L

    		Human HEK293
    CD299 protein showcases an unconventional genetic architecture with a non-canonical intron-exon splice junction, highlighting unique structural features. CD299 Protein, Human (HEK293, His-Flag) is the recombinant human-derived CD299 protein, expressed by HEK293 , with N-Flag, N-8*His labeled tag. The total length of CD299 Protein, Human (HEK293, His-Flag) is 304 a.a., with molecular weight of 35-40 kDa.
  • HY-P72750
    CD161 Protein, Human (HEK293, Fc)

    Killer cell lectin-like receptor subfamily B member 1; NKR-P1A; CD161; KLRB1; CLEC5B

    		Human HEK293
    CD161 protein plays a crucial role in inhibiting NK cell toxicity by activating specific acid sphingomyelinase/SMPD1 and increasing ceramide levels. Activation stimulates AKT1/PKB and RPS6KA1/RSK1 kinases, enhancing anti-CD3-induced T cell proliferation. CD161 Protein, Human (HEK293, Fc) is the recombinant human-derived CD161 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CD161 Protein, Human (HEK293, Fc) is 159 a.a., with molecular weight of 55-70 kDa.
  • HY-P72967
    Dectin-2/CLEC6A Protein, Mouse (HEK293, His)

    C-type lectin domain family 6 member A; Dectin-2; Clec6a; Clec4n; Clecsf10

    		Mouse HEK293
    Dectin-2/CLEC6A protein has carbohydrate binding and pattern recognition receptor activities, and is involved in the positive regulation of I-kappaB kinase/NF-kappaB signaling, immune response regulation, and fungal response. It is predicted to reside in membranes, particularly on the outside of the plasma membrane, and it is expressed in a variety of tissues, including bone marrow, embryos, lungs, spleen, and thymus. Dectin-2/CLEC6A Protein, Mouse (HEK293, His) is the recombinant mouse-derived Dectin-2/CLEC6A protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Dectin-2/CLEC6A Protein, Mouse (HEK293, His) is 166 a.a., with molecular weight of ~23 kDa.
  • HY-P75336
    CLEC1B/CLEC-2 Protein, Human (HEK293, His)

    C-type lectin domain family 1 member B; CLEC1B; CLEC2

    		Human HEK293
    CLEC1B/CLEC-2 protein is a C-type lectin-like receptor that acts as a platelet receptor and snake venom protein receptor for PDPN in microbial infections. Upon activation, it initiates a signaling cascade involving SRC and SYK kinases, leading to PLCG2 activation. CLEC1B/CLEC-2 Protein, Human (HEK293, His) is the recombinant human-derived CLEC1B/CLEC-2 protein, expressed by HEK293 , with N-His labeled tag. The total length of CLEC1B/CLEC-2 Protein, Human (HEK293, His) is 172 a.a., with molecular weight of 35-38 kDa.
  • HY-P76219
    CD299 Protein, Human (HEK293, Fc)

    C-type lectin domain family 4 member M; DC-SIGNR; DC-SIGN2; L-SIGN; CD299; CLEC4M; CD209L

    		Human HEK293
    The CD299 protein is an important C-type lectin that plays a role in cell adhesion and pathogen recognition. It can identify pathogens such as Mycobacterium tuberculosis, Ebola virus, hepatitis C, HIV-1, influenza A, West Nile virus and SARS-CoV. CD299 Protein, Human (HEK293, Fc) is the recombinant human-derived CD299 protein, expressed by HEK293 , with N-hFc labeled tag. The total length of CD299 Protein, Human (HEK293, Fc) is 322 a.a., with molecular weight (glycosylation form) of 65.83 kDa.
  • HY-P76830
    CLEC2B Protein, Human (HEK293, Fc)

    C-type lectin domain family 2 member B; AICL; CLECSF2; IFNRG1

    		Human HEK293
  • HY-P77903
    CLEC12A/MICL Protein, Cynomolgus (HEK293, His)

    MICL; CLL-1; CLEC12A; CLL1; DCAL2; DCAL-2; CD371; CD303; CLECSF11; CLECSF7; DLEC; HECL; PRO34150; DCAL-2

    		Cynomolgus HEK293
    CLEC12A/MICL Protein is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. CLEC12A is a cell surface receptor known to regulate signaling cascades and facilitate the tyrosine phosphorylation of target MAP kinases. It interacts with PTPN6 and PTPN11, indicating its involvement in intricate cellular signaling processes. CLEC12A/MICL Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived CLEC12A/MICL protein, expressed by HEK293 , with N-His labeled tag. The total length of CLEC12A/MICL Protein, Cynomolgus (HEK293, His) is 201 a.a., with molecular weight of 38-60 kDa.
  • HY-P75296
    Dectin-1/CLEC7A Protein, Mouse (HEK293, His)

    C-type lectin domain family 7 member A; Clecsf12; CD369; Clec7a

    		Mouse HEK293
    Dectin-1/CLEC7A protein has (1->3)-β-D-glucan binding and pattern recognition receptor activity, participates in immune responses and recognizes specific structures. It regulates cytokine production and responds to fungal pathogens while being active on the cell surface. Dectin-1/CLEC7A Protein, Mouse (HEK293, His) is the recombinant mouse-derived Dectin-1/CLEC7A protein, expressed by HEK293 , with N-His labeled tag. The total length of Dectin-1/CLEC7A Protein, Mouse (HEK293, His) is 176 a.a., with molecular weight of 30-37 kDa.
  • HY-P71607
    KLRG1 Protein, Human (His-SUMO)

    2F1 Ag; 2F1; C type lectin domain family 15 member A; C-type lectin domain family 15 member A; CLEC15A; KLRG 1; KLRG1; KLRG1 protein

    		Human E. coli
    KLRG1 Protein exerts inhibitory effects on NK cells and T-cells by binding to their non-MHC ligands, potentially recognizing "missing self" through conserved sites on classical cadherins like E-cadherin/CDH1, N-cadherin/CDH2, and R-cadherin/CDH4. Existing as a monomer and homodimer connected by disulfide bonds, KLRG1 interacts with PTPN11 and INPP5D via its ITIM motif, suggesting involvement in signal transduction pathways. KLRG1 Protein, Human (His-SUMO) is the recombinant human-derived KLRG1 protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag. The total length of KLRG1 Protein, Human (His-SUMO) is 136 a.a., with molecular weight of ~31.5 kDa.
  • HY-P73835
    LOX-1/OLR1 Protein, Rat (HEK293, His)

    Oxidized low-density lipoprotein receptor 1; LOX-1; OLR1; CLEC8A

    		Rat HEK293
    The LOX-1/OLR1 protein plays an important role as a receptor that recognizes, internalizes, and degrades oxidatively modified low-density lipoprotein (oxLDL), a marker of atherosclerosis, in vascular endothelial cells. OxLDL induces endothelial dysfunction, triggering pro-inflammatory responses, oxidative conditions, and apoptosis. LOX-1/OLR1 Protein, Rat (HEK293, His) is the recombinant rat-derived LOX-1/OLR1 protein, expressed by HEK293 , with N-His labeled tag. The total length of LOX-1/OLR1 Protein, Rat (HEK293, His) is 305 a.a., with molecular weight of 43-47 kDa.
  • HY-P74205
    DC-SIGN/CD209 Protein, Rhesus Macaque (HEK293, His)

    CD209 antigen; DC-SIGN1; CD209

    		Rhesus Macaque HEK293
    DC-SIGN/CD209 Protein, is a C-type lectin receptor present on the surface of both macrophages and dendritic cells (DCs), serves as a pivotal pathogen-recognition receptor, playing a crucial role in initiating the primary immune response. It mediates endocytosis and subsequent degradation of pathogens within lysosomal compartments. On DCs, it acts as a high-affinity receptor for ICAM2 and ICAM3, binding to mannose-like carbohydrates. DC-SIGN/CD209 Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived DC-SIGN/CD209 protein, expressed by HEK293 , with N-His labeled tag. The total length of DC-SIGN/CD209 Protein, Rhesus Macaque (HEK293, His) is 320 a.a., with molecular weight of ~44 kDa.
Cat. No. Product Name Effect Purity