1. Recombinant Proteins
  2. Receptor Proteins
  3. Pattern Recognition Receptors
  4. C-type Lectin Receptors

C-type Lectin Receptors

C-type lectin receptors (CLRs) are a large family of transmembrane pattern recognition receptors (PRRs) involved in recognition and induction of adaptive immune responses to pathogens. CLRs comprise a large family of receptors which bind carbohydrates. They are characterized by one or more C-type lectin-like domains (CTLDs) and classified into 17 groups based on features including phylogeny and structure. CLRs are prominently expressed on myeloid cells. Based on their intracellular signaling motifs, CLRs can be further subdivided into: 1) Activation spleen tyrosine kinase (Syk)-coupled CLRs with immunoreceptor tyrosine-based activating motif (ITAM) or hemITAM, such as Mincle, Dectin-1 and Dectin-2; 2) Inhibitory CLRs with immunoreceptor tyrosine-based inhibition motif (ITIM) domains, such as DCIR; 3) A group of CLRs lacking typical signaling motifs, such as Mannose receptor, DEC-205 and DC-SIGN. Upon ligand binding, CLRs stimulate intracellular signaling cascades that induce the production of inflammatory cytokines and chemokines, consequently triggering innate and adaptive immunity to pathogens.

Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name Effect Purity