C-type Lectin Receptors
null C-type lectin receptors (CLRs) are a large family of transmembrane pattern recognition receptors (PRRs) involved in recognition and induction of adaptive immune responses to pathogens. CLRs comprise a large family of receptors which bind carbohydrates. They are characterized by one or more C-type lectin-like domains (CTLDs) and classified into 17 groups based on features including phylogeny and structure. CLRs are prominently expressed on myeloid cells. Based on their intracellular signaling motifs, CLRs can be further subdivided into: 1) Activation spleen tyrosine kinase (Syk)-coupled CLRs with immunoreceptor tyrosine-based activating motif (ITAM) or hemITAM, such as Mincle, Dectin-1 and Dectin-2; 2) Inhibitory CLRs with immunoreceptor tyrosine-based inhibition motif (ITIM) domains, such as DCIR; 3) A group of CLRs lacking typical signaling motifs, such as Mannose receptor, DEC-205 and DC-SIGN. Upon ligand binding, CLRs stimulate intracellular signaling cascades that induce the production of inflammatory cytokines and chemokines, consequently triggering innate and adaptive immunity to pathogens.
- CLL-1 (8)
- BDCA-2 (7)
- MDL-1/CLEC5A (7)
- Dectin-1 (6)
- Mannose Receptor (6)
- Killer Cell Lectin Like Receptor G1 (KLRG1) (6)
- CLEC2D (4)
- LOX-1 (4)
- CD69 (4)
- CD161/KLRB1 (4)
- C-Type Lectin Domain Family 10 Member A/CD301 (4)
- CD302/CLEC13A (4)
- CD367/CLEC4A (4)
- DC-SIGN2/CLEC4M/CD299 (3)
- CLEC-1 (3)
- CLEC-2 (3)
- CLEC-6 (3)
- Macrophage-inducible C-type Lectin/CLEC4E (3)
- CLEC14A (3)
- Langerin/CD207 (3)
- CLEC4A3 (2)
- CLEC4F (2)
- C-Type Lectin Domain Containing 6A/Dectin-2 (2)
- DNGR-1/CLEC9A (2)
- Collectin Liver 1 (2)
- Collectin-12 (2)
- CLEC2B (1)
- C-Type Lectin Domain Family 3 Member A (CLEC3A) (1)
- CLEC4B2 (1)
- KLRB1F/CD161f (1)
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C-type Lectin Receptors 組換えタンパク質 (109)
- 生物種:
- 由来:
- 生物種:
- 由来:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- 分子式: Human
- 分子量: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
