DC-SIGN2/CLEC4M/CD299
CD299, commonly called L-SIGN or DC-SIGNR and encoded by CLEC4M, is the close paralog of DC-SIGN. Unlike its dendritic cell-restricted relative, L-SIGN expression is concentrated on liver sinusoidal endothelial cells, on placental macrophages and in the lymph node medulla, anatomical sites that interface with blood-borne pathogens. Its extracellular carbohydrate-recognition domain and tetrameric neck architecture mirror DC-SIGN and bind high-mannose glycans, enabling capture of a similar spectrum of viruses, including SARS coronavirus, HIV, HCV, dengue virus and SARS-CoV-2, as well as mycobacteria. Pathogen capture by L-SIGN can facilitate either clearance or trans-infection, and neck-region repeat polymorphisms influence susceptibility to several infections.
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DC-SIGN2/CLEC4M/CD299 Recombinant Proteins (3)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
