Cathepsin D
Cathepsin D (CTSD) is the most abundant lysosomal aspartic endoprotease and, unlike the papain-family cysteine cathepsins, belongs to the pepsin family of aspartic proteases. Synthesized as a preproenzyme, it is glycosylated and targeted through the mannose-6-phosphate pathway to lysosomes, where its propeptide is autocatalytically removed. It degrades a broad range of internalized and endogenous proteins and has been implicated in apoptosis regulation through its ability to promote mitochondrial outer membrane permeabilization. Germline CTSD loss-of-function causes congenital neuronal ceroid lipofuscinosis (CLN10), and the protease is also studied as a prognostic marker in breast cancer.
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Cathepsin D Recombinant Proteins (5)
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Inhibitors & Agonists (15)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
