PI4K
Four genes encode the human PI4-kinases that make phosphatidylinositol 4-phosphate: the type III enzymes PI4KA and PI4KB, and the type II enzymes PI4K2A and PI4K2B. PI4KB is anchored at the Golgi through interactions with ACBD3, Rab1 and Arf1 and supplies PI4P for lipid transfer and secretory trafficking. PI4KA works at the plasma membrane inside a complex with TTC7 and FAM126A that maintains PI(4,5)P2 pools, and mutations in those partners cause a neonatal leukodystrophy with gastrointestinal defects. PI4K2A and PI4K2B are membrane-integral kinases acting on endolysosomal compartments. Enteroviruses and hepatitis C virus hijack PI4KB to build replication organelles, making the family an antiviral target.
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PI4K Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- 화학식: Human
- 분자량: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
