1. GPCR/G Protein
  2. Bradykinin Receptor

Bradykinin Receptor

Bradykinin is a potent vasodilator peptide that exerts its vasodilatory action through stimulation of specific endothelial B2 receptors, thereby causing the release of prostacyclin, NO, and EDHF.

Bradykinin (BK) has been reported to be involved in the progression of many types of cancer. Two bradykinin receptors, bradykinin B1 receptor (B1R) and bradykinin B2 receptor (B2R), are significantly expressed in all the tested colorectal cancer cells. Repression of B2R, but not B1R, attenuates the BK-mediated invasion and migration, and inhibits ERK1/2 activation and IL-6 production. Moreover, blocking of the ERK pathway decreases the BK-mediated IL-6 production. In addition, IL-6 repression suppresses the effects of BK on colorectal cancer cell invasion and migration.

Bradykinin, the enzymatic product of kallikrein-kinin system (KKS), is a major modulator of Ang II actions on blood volume, vascular reactivity and salt sensitivity.

Bradykinin Receptor Related Products (11):

Cat. No. Product Name Effect Purity
  • HY-17446
    Icatibant Antagonist
    Icatibant(HOE-140) is a selective and specific antagonist of bradykinin B2 receptor with IC50 and Ki of 1.07 nM and 0.798 nM respectively.
  • HY-P0206
    Bradykinin 98.97%
    Bradykinin is an active peptide that is generated by the kallikrein-kinin system. It is a inflammatory mediator and also recognized as a neuromediator and regulator of several vascular and renal functions. Sequence: Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg.
  • HY-15039
    SSR240612 Antagonist 99.19%
    SSR240612 is a potent, and orally active specific non-peptide bradykinin B1 receptor antagonist, with Kis of 0.48 nM and 0.73 nM for B1 kinin receptors of human fibroblast MRC5 and HEK cells expressing human B1 receptors, 481 nM and 358 nM for B2 receptors of guinea pig ileum membranes and CHO cells expressing human B1 receptor, respectively.
  • HY-P0298
    [Des-Arg9]-Bradykinin Agonist
    [Des-Arg9]-Bradykinin is a Bradykinin (B1) receptor agonist that displays selectivity for B1 over B2 receptors. Sequence: Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe.
  • HY-15043
    ELN-441958 Antagonist 98.94%
    ELN-441958 is a potent, neutral antagonist of B1 receptor, inhibits the binding of the B1 agonist ligand [3H]DAKD to IMR-90 cells with Ki of 0.26 nM. ELN-441958 is highly selective for B1 over B2 receptors, and >500/ 2000-fold selective for the B1 over μ/δ-opioid receptor.
  • HY-100301
    FR167344 free base Antagonist
    FR167344 free base is an orally active, nonpeptide bradykinin receptor B2 antagonist. FR167344 free base shows a high affinity binding to the B2 receptor with an IC50 value of 65 nM and no binding affinity for the B1 receptor.
  • HY-P1497
    Bradykinin 1-3
    Bradykinin (1-3) is a 3-amino acid residue peptide. Bradykinin (1-3) is an amino-truncated Bradykinin peptide, cleaved by Prolyl endopeptidase.
  • HY-P1488
    Bradykinin 1-5
    Bradykinin (1-5) is a major stable metabolite of Bradykinin, formed by the proteolytic action of angiotensin-converting enzyme (ACE).
  • HY-P1469
    Bradykinin 1-6
    Bradykinin (1-6) is an amino-truncated Bradykinin peptide. Bradykinin (1-6) is a stable metabolite of Bradykinin, cleaved by carboxypeptidase Y (CPY).
  • HY-P1484
    Bradykinin 1-7
    Bradykinin (1-7) is an amino-truncated Bradykinin peptide. Bradykinin (1-7) is a metabolite of Bradykinin, cleaved by endopeptidase.
  • HY-P1490
    Bradykinin 2-9
    Bradykinin (2-9) is an amino-truncated Bradykinin peptide. Bradykinin (2-9) is a metabolite of Bradykinin, cleaved by Aminopeptidase P.
Isoform Specific Products

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