2. GPCR/G Protein Stem Cell/Wnt MAPK/ERK Pathway
  3. Bradykinin Receptor ERK
  4. [Tyr8] Bradykinin

[Tyr8] Bradykinin is a B2 kinin receptor agonist. [Tyr8] Bradykinin also stimulates ERK1/2 phosphorylation. [Tyr8] Bradykinin can be used as an internal standard.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

[Tyr8] Bradykinin Chemical Structure

[Tyr8] Bradykinin Chemical Structure

CAS No. : 32222-00-7

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10 mg USD 225 In-stock
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Based on 1 publication(s) in Google Scholar

[Tyr8] Bradykinin Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

[Tyr8] Bradykinin is a B2 kinin receptor agonist. [Tyr8] Bradykinin also stimulates ERK1/2 phosphorylation. [Tyr8] Bradykinin can be used as an internal standard[1].

IC50 & Target

ERK1

 

ERK2

 

In Vitro

[Tyr8] Bradykinin (10 nM, 2 min) produces a rapid increase in phosphorylated ERK1/2[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

[Tyr8] Bradykinin Related Antibodies

Western Blot Analysis[1]

Cell Line: Serum-deprived trabecular meshwork cells
Concentration: 10 nM
Incubation Time: 2 min
Result: Produced a rapid increase in phosphorylated ERK1/2 that was equivalent in magnitude to that observed for Bradykinin (HY-P0206).
Molecular Weight

1076.21

Formula

C50H73N15O12
CAS No.
Appearance

Solid

Color

White to off-white

Sequence Shortening

RPPGFSPYR
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
Purity & Documentation
References
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[Tyr8] Bradykinin Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

[Tyr8] Bradykinin32222-00-7Bradykinin ReceptorERKExtracellular signal regulated kinasesinternal standardBradykininphosphorylationInhibitorinhibitorinhibit

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Cat. No.:
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