1. Membrane Transporter/Ion Channel
  2. P-glycoprotein

P-glycoprotein

P-glycoprotein (P-gp) also known as multidrug resistance protein 1 (MDR1) is an important protein of the cell membrane that pumps many foreign substances out of cells. More formally, it is an ATP-dependent efflux pump with broad substrate specificity. P-gp is extensively distributed and expressed in the intestinal epithelium where it pumps xenobiotics (such as toxins or drugs) back into the intestinal lumen, in liver cells where it pumps them into bile ducts, in the cells of the proximal tubular of the kidney where it pumps them into urine-conducting ducts, and in the capillary endothelial cells comprising the blood–brain barrier and blood-testis barrier, where it pumps them back into the capillaries. Some cancer cells also express large amounts of P-gp, which renders these cancers multi-drug resistant. P-gp is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood–brain barrier.

P-glycoprotein Related Products (22):

Cat. No. Product Name Effect Purity
  • HY-50879
    Elacridar Inhibitor 98.47%
    Elacridar is a potent P-glycoprotein (Pgp) and BCRP inhibitor.
  • HY-17384
    Valspodar Inhibitor 99.27%
    Valspodar is a P-glycoprotein (P-gp) inhibitor widely used as overcoming multidrug resistance modulator.
  • HY-50671
    Zosuquidar trihydrochloride Inhibitor 98.75%
    Zosuquidar trihydrochloride is an inhibitor of P-glycoprotein with a Ki value of 59 nM.
  • HY-10550
    Tariquidar Inhibitor 98.57%
    Tariquidar is a potent and specific inhibitor of P-glycoprotein (P-gp) with the high affinity (Kd=5.1±0.9 nM).
  • HY-10550A
    Tariquidar methanesulfonate, hydrate Inhibitor 98.02%
    Tariquidar methanesulfonate, hydrate is a potent and specific inhibitor of P-glycoprotein (P-gp) with a Kd of 5.1 nM.
  • HY-N5077
    Sinapine Inhibitor 99.33%
    Sinapine is an alkaloid from seeds of the cruciferous species which shows favorable biological activities such as antioxidant and radio-protective activities.
  • HY-106004
    Zamicastat Inhibitor
    Zamicastat is a concentration-dependent dual P-gp and BCRP inhibitor with IC50 values of 73.8±7.2 μM and 17.0±2.7 μM, respectively.
  • HY-13646A
    HM30181 mesylate Inhibitor
    HM30181 mesylate is a competitive and potent P-glycoprotein inhibitor.
  • HY-N0450
    Sinapine thiocyanate Inhibitor >98.0%
    Sinapine is an alkaloid from seeds of the cruciferous species which shows favorable biological activities such as antioxidant and radio-protective activities.
  • HY-11018
    Risperidone Inhibitor 99.16%
    Risperidone is a serotonin 5-HT2 receptor blocker, P-Glycoprotein inhibitor and potent dopamine D2 receptor antagonist, with Kis of 4.8, 5.9 nM for 5-HT2A and dopamine D2 receptor, respectively.
  • HY-N0144
    Piperine Inhibitor 98.76%
    Piperine, a natural alkaloid isolated from Piper nigrum L, inhibits P-glycoprotein and CYP3A4 activities with an IC50 value of 61.94±0.054 μg/mL in HeLa cell.
  • HY-13646
    HM30181 Inhibitor
    HM30181 is a potent and selective inhibitor of P-glycoprotein.
  • HY-15255
    Zosuquidar Inhibitor 98.33%
    Zosuquidar (LY335979) is a potent negative modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM.
  • HY-N0797
    (20S)-Protopanaxadiol Inhibitor >98.0%
    protopanaxadiol-type ginseng saponin; apoptosis inducer.
  • HY-17013A
    Dofequidar fumarate Inhibitor 99.66%
    Dofequidar fumarate(MS-209 fumarate), an orally active quinoline compound, has been reported to overcome MDR by inhibiting ABCB1/P-gp, ABCC1/MDR-associated protein 1, or both.
  • HY-19626
    NSC23925 Inhibitor 99.23%
    NSC23925 is a novel, selective and effective P-glycoprotein (Pgp) inhibitor.
  • HY-17013
    Dofequidar Inhibitor
    Dofequidar(MS-209) is a novel quinoline compound, which can reverse P-glycoprotein (P-gp)-mediated MDR.
  • HY-N0854
    Alisol F Inhibitor
    Alisol F is a natural product.
  • HY-101530
    Polyoxyethylene stearate
    Polyoxyethylene stearate (POES) is a non-ionic emulsifying agent.
  • HY-50880
    Elacridar hydrochloride Inhibitor
    Elacridar Hcl (GF120918; GW0918) is a P-glycoprotein inhibitor, and has been used both in vitro and in vivo as a tool inhibitor of P-glycoprotein (Pgp) to investigate the role of transporters in the disposition of various test molecules.
Isoform Specific Products

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.