1. Signaling Pathways
  2. Membrane Transporter/Ion Channel
  3. P-glycoprotein

P-glycoprotein

P-glycoprotein (P-gp) also known as multidrug resistance protein 1 (MDR1) is an important protein of the cell membrane that pumps many foreign substances out of cells. More formally, it is an ATP-dependent efflux pump with broad substrate specificity. P-gp is extensively distributed and expressed in the intestinal epithelium where it pumps xenobiotics (such as toxins or drugs) back into the intestinal lumen, in liver cells where it pumps them into bile ducts, in the cells of the proximal tubular of the kidney where it pumps them into urine-conducting ducts, and in the capillary endothelial cells comprising the blood–brain barrier and blood-testis barrier, where it pumps them back into the capillaries. Some cancer cells also express large amounts of P-gp, which renders these cancers multi-drug resistant. P-gp is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood–brain barrier.

P-glycoprotein Related Products (25):

Cat. No. Product Name Effect Purity
  • HY-50879
    Elacridar Inhibitor 98.47%
    Elacridar is a potent P-glycoprotein (Pgp) and BCRP inhibitor.
  • HY-17384
    Valspodar Inhibitor 99.27%
    Valspodar is a selective P-glycoprotein inhibitor that has been used as an experimental cancer treatment and chemosensitizer.
  • HY-50671
    Zosuquidar trihydrochloride Inhibitor 98.75%
    Zosuquidar trihydrochloride is an inhibitor of P-glycoprotein with a Ki value of 59 nM.
  • HY-10550
    Tariquidar Inhibitor 98.57%
    Tariquidar is a potent and specific inhibitor of P-glycoprotein (P-gp) with the high affinity (Kd=5.1±0.9 nM).
  • HY-10550A
    Tariquidar methanesulfonate, hydrate Inhibitor 98.02%
    Tariquidar methanesulfonate, hydrate is a potent and specific inhibitor of P-glycoprotein (P-gp) with a Kd of 5.1 nM.
  • HY-112912
    P-gp modulator 1
    P-gp modulator 1 is a high affinity, orally available modulator of P-glycoprotein (Pgp), can reverse the Pgp-mediated multidrug resistance ((MDR).
  • HY-101791
    P-gp inhibitor 1 Inhibitor
    P-gp inhibitor 1 is a novel inhibitor reversing P-glycoprotein-mediated multidrug resistance.
  • HY-107643
    Reversan Inhibitor
    Reversan (CBLC4H10) is a potent and nontoxic multidrug resistance-associated protein 1 (MRP1) and P-glycoprotein (Pgp) inhibitor.
  • HY-11018
    Risperidone Inhibitor 99.16%
    Risperidone is a serotonin 5-HT2 receptor blocker, P-Glycoprotein inhibitor and potent dopamine D2 receptor antagonist, with Kis of 4.8, 5.9 nM for 5-HT2A and dopamine D2 receptor, respectively.
  • HY-15255
    Zosuquidar Inhibitor 98.33%
    Zosuquidar (LY335979) is a potent negative modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM.
  • HY-N0450
    Sinapine thiocyanate Inhibitor 98.32%
    Sinapine is an alkaloid from seeds of the cruciferous species which shows favorable biological activities such as antioxidant and radio-protective activities.
  • HY-13646
    Encequidar Inhibitor 98.12%
    Encequidar (HM30181) is a potent and selective inhibitor of P-glycoprotein.
  • HY-N0144
    Piperine Inhibitor 98.76%
    Piperine, a natural alkaloid isolated from Piper nigrum L, inhibits P-glycoprotein and CYP3A4 activities with an IC50 value of 61.94±0.054 μg/mL in HeLa cell.
  • HY-N5077
    Sinapine Inhibitor 99.72%
    Sinapine is an alkaloid from seeds of the cruciferous species which shows favorable biological activities such as antioxidant and radio-protective activities.
  • HY-N0797
    (20S)-Protopanaxadiol Inhibitor >98.0%
    (20S)-Protopanaxadiol (20-Epiprotopanaxadiol) is an aglycon metabolic derivative of the protopanaxadiol-type ginseng saponin; apoptosis inducer.
  • HY-17013A
    Dofequidar fumarate Inhibitor 99.99%
    Dofequidar fumarate(MS-209 fumarate), an orally active quinoline compound, has been reported to overcome MDR by inhibiting ABCB1/P-gp, ABCC1/MDR-associated protein 1, or both.
  • HY-19626
    NSC23925 Inhibitor 99.23%
    NSC23925 is a novel, selective and effective P-glycoprotein (Pgp) inhibitor.
  • HY-106004
    Zamicastat Inhibitor 99.95%
    Zamicastat (BIA 5-1058) is a dopamine β-hydroxylase (DBH) inhibitor that could cross the blood-brain barrier (BBB) and cause central as well as peripheral effects. Zamicastat is also a concentration-dependent dual P-gp and BCRP inhibitor with IC50 values of 73.8 μM and 17.0 μM, respectively. Reduces high blood pressure.
  • HY-17013
    Dofequidar Inhibitor
    Dofequidar(MS-209) is a novel quinoline compound, which can reverse P-glycoprotein (P-gp)-mediated MDR.
  • HY-N0854
    Alisol F Inhibitor
    Alisol F is a natural product.
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