1. Membrane Transporter/Ion Channel Metabolic Enzyme/Protease Apoptosis Anti-infection
  2. Potassium Channel Cytochrome P450 Apoptosis Parasite
  3. Quinidine (15% dihydroquinidine)

Quinidine (15% dihydroquinidine) 

Cat. No.: HY-B1751 Purity: 99.19%
COA Handling Instructions

Quinidine (15% dihydroquinidine) is an antiarrhythmic agent. Quinidine is a potent, orally active, selective cytochrome P450db inhibitor. Quinidine is also a K+ channel blocker with an IC50 of 19.9 μM, and can induce apoptosis. Quinidine can be used for malaria research.

For research use only. We do not sell to patients.

Quinidine (15% dihydroquinidine) Chemical Structure

Quinidine (15% dihydroquinidine) Chemical Structure

CAS No. : 56-54-2

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Solid + Solvent
10 mM * 1 mL in DMSO
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Solid
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Customer Review

Based on 14 publication(s) in Google Scholar

Other Forms of Quinidine (15% dihydroquinidine):

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Description

Quinidine (15% dihydroquinidine) is an antiarrhythmic agent. Quinidine is a potent, orally active, selective cytochrome P450db inhibitor. Quinidine is also a K+ channel blocker with an IC50 of 19.9 μM, and can induce apoptosis. Quinidine can be used for malaria research[1][2][3][4].

IC50 & Target

Plasmodium

 

In Vitro

Quinidine shows cytotoxicity against MES-SA cells, and induces apoptosis[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[4]

Cell Line: MES-SA and MESSA/DX5 cells
Concentration: 10 μM
Incubation Time: 24 hours
Result: Showed cytotoxicity against MES-SA cells in a concentration-dependent manner.

Apoptosis Analysis[4]

Cell Line: MES-SA and MESSA/DX5 cells
Concentration: 10 μM
Incubation Time: 24 hours
Result: Increased the apoptotic portion sub-G1 DNA contents induced by paclitaxel, while paclitaxel had no effect on sub-G1 DNA contents undergoing apoptosis.
In Vivo

Quinidine shows effects on the PTZ-induced seizure threshold[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male mice of the NMRI strain (age 5-6 weeks and weight 25-30 g)[5
Dosage: 10, 20, and 30 mg/kg
Administration: Intraperitoneal injection; 10, 20, and 30 mg/kg; once
Result: Increased the threshold dose for the onset to tonic hind limb extension at a dose of 30 mg/kg, compared to the saline-treated control group (p<0.05).
Molecular Weight

324.42

Formula

C20H24N2O2

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C=C[C@H]1C[N@](CC[C@H]1C2)[C@@]2([H])[C@@H](O)C3=CC=NC4=CC=C(OC)C=C34

Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 1 years; -20°C, 6 months (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (154.12 mM)

Ethanol : 14.29 mg/mL (44.05 mM; ultrasonic and warming and heat to 60°C)

H2O : 0.67 mg/mL (2.07 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0824 mL 15.4121 mL 30.8242 mL
5 mM 0.6165 mL 3.0824 mL 6.1648 mL
10 mM 0.3082 mL 1.5412 mL 3.0824 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (7.71 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (7.71 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (7.71 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 99.19%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Quinidine (15% dihydroquinidine)
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HY-B1751
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