2. Anti-infection Membrane Transporter/Ion Channel Metabolic Enzyme/Protease Apoptosis
  3. Parasite Potassium Channel Cytochrome P450 Apoptosis
  4. Quinidine gluconic acid

Quinate is an antiarrhythmic agent. Quinate is a potent, orally active, selective cytochrome P450db inhibitor. Quinate is also a K+ channel blocker with an IC50 of 19.9 μM, and can induce apoptosis. Quinate can be used for malaria research.

For research use only. We do not sell to patients.

CAS No. : 7054-25-3

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Quinidine gluconic acid Related Antibodies

Top Publications Citing Use of Products

    Quinidine gluconic acid purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Aug 19:e05666.  [Abstract]

    Quinidine rescued [Mg2⁺]i levels in LPS‐treated or TRPM7‐silenced DPSCs and SCAP.

    Quinidine gluconic acid purchased from MedChemExpress. Usage Cited in: J Hazard Mater. 2021 Aug 15:416:125764.  [Abstract]

    Effects of CYP enzymes inhibitors on metabolic rates of cyproconazole stereoisomers in the in vitro incubation mixtures with RLMs. The asterisks (*) indicates the significant difference in metabolic rates under inhibition compared to the control.

    Quinidine gluconic acid purchased from MedChemExpress. Usage Cited in: Front Pharmacol. 2020 Jul 31;11:1038.  [Abstract]

    Cell cycle relative proteins/genes (CyclinD1, CDK4, P21 and P27) level were assessed in HConFs after Quinidine treatment by western blot.

    Quinidine gluconic acid purchased from MedChemExpress. Usage Cited in: Front Pharmacol. 2020 Jul 31;11:1038.  [Abstract]

    Cell cycle relative proteins/genes (CyclinD1, CDK4, P21 and P27) level were assessed in HConFs after Atropine/Quinidine treatment by qRT-PCR.

    Quinidine gluconic acid purchased from MedChemExpress. Usage Cited in: Environ Int. 2019 Jun;127:694-703.  [Abstract]

    CYP2D6 has contributed in the enantioselectivity of IFP and ICPO because the EF value of the KND-supplemented group follows a doseeffect relationship and the difference in the EF values was over 10% relative to the DMSO control group.

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    Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

    View All Cytochrome P450 Isoform Specific Products:

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    CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A CYP3A4 CYP17A1

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    Description

    Quinate is an antiarrhythmic agent. Quinate is a potent, orally active, selective cytochrome P450db inhibitor. Quinate is also a K+ channel blocker with an IC50 of 19.9 μM, and can induce apoptosis. Quinate can be used for malaria research[1][2][3][4].

    IC50 & Target

    Plasmodium

     

    In Vitro

    Quinate shows cytotoxicity against MES-SA cells, and induces apoptosis[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Quinidine gluconic acid Related Antibodies

    Cell Cytotoxicity Assay[4]

    Cell Line: MES-SA and MESSA/DX5 cells
    Concentration: 10 μM
    Incubation Time: 24 hours
    Result: Showed cytotoxicity against MES-SA cells in a concentration-dependent manner.

    Apoptosis Analysis[4]

    Cell Line: MES-SA and MESSA/DX5 cells
    Concentration: 10 μM
    Incubation Time: 24 hours
    Result: Increased the apoptotic portion sub-G1 DNA contents induced by paclitaxel, while paclitaxel had no effect on sub-G1 DNA contents undergoing apoptosis.
    In Vivo

    Quinate shows effects on the PTZ-induced seizure threshold[5].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male mice of the NMRI strain (age 5-6 weeks and weight 25-30 g)[5]
    Dosage: 10, 20, and 30 mg/kg
    Administration: Intraperitoneal injection; 10, 20, and 30 mg/kg; once
    Result: Increased the threshold dose for the onset to tonic hind limb extension at a dose of 30 mg/kg, compared to the saline-treated control group (p<0.05).
    Molecular Weight

    520.57

    Formula

    C26H36N2O9
    CAS No.
    SMILES

    C=C[C@H]1C[N@](CC[C@H]1C2)[C@@]2([H])[C@@H](O)C3=CC=NC4=CC=C(OC)C=C34.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    Quinidine gluconic acid Related Classifications

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Quinidine7054-25-3ParasitePotassium ChannelCytochrome P450ApoptosisKcsACYPsoral activitymalariaMES-SAMESSA/DX5Inhibitorinhibitorinhibit

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