1. Cell Cycle/DNA Damage
    Cytoskeleton
    Antibody-drug Conjugate/ADC Related
    Autophagy
  2. Microtubule/Tubulin
    ADC Cytotoxin
    Autophagy
  3. Paclitaxel

Paclitaxel (Synonyms: Taxol)

Cat. No.: HY-B0015 Purity: 99.97%
Handling Instructions

Paclitaxel (Taxol), a naturally occurring antineoplastic agent, stabilizes tubulin polymerization, resulting in arrest at the G2/M phase of the cell cycle and apoptotic cell death.

For research use only. We do not sell to patients.

Paclitaxel Chemical Structure

Paclitaxel Chemical Structure

CAS No. : 33069-62-4

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10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
50 mg USD 60 In-stock
Estimated Time of Arrival: December 31
100 mg USD 96 In-stock
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Customer Review

Based on 30 publication(s) in Google Scholar

Top Publications Citing Use of Products

    Paclitaxel purchased from MCE. Usage Cited in: Am J Cancer Res. 2017 Apr 1;7(4):903-912.

    Synergistic inhibition of colony formation of ATC cells by Lenvatinib and Paclitaxel. Representative images of colony formation in C643 cells treated with vehicle control (DMSO) or Lenvatinib and Paclitaxel at the indicated concentrations, individually or in combination, are shown in left panel. Quantitative analysis of colony numbers is shown in right panel.

    Paclitaxel purchased from MCE. Usage Cited in: Biochim Biophys Acta. 2018 May;1862(5):1134-1147.

    The effects of CS1 on polymerized microtubules are also investigated using a cellular tubulin polymer assay. Nocodazole (1 μM) and Paclitaxel (1.5 μM) are used as depolymerization and polymerization controls, respectively.

    Paclitaxel purchased from MCE. Usage Cited in: J Agric Food Chem. 2019 Feb 13;67(6):1656-1665.

    Western blot image and statistical analysis of phosphorylated γH2AX levels in HT-29 cells with different treatments after 48 h. Myricetin and PTX used are 32 μM and 100 nM, respectively.
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    Description

    Paclitaxel (Taxol), a naturally occurring antineoplastic agent, stabilizes tubulin polymerization, resulting in arrest at the G2/M phase of the cell cycle and apoptotic cell death[1][2].

    IC50 & Target

    Traditional Cytotoxic Agents

     

    In Vitro

    Paclitaxel (20 nM; 48 hours) induces programmed cell death and exists a block at the G2/M phase of the cell cycle[1].
    Paclitaxel (20 nM; 48 hours) induces a consistent increase in the level of p53[1].

    Apoptosis Analysis[1]

    Cell Line: MCF-7, MDA-MB-231 cells
    Concentration: 20 nM
    Incubation Time: 48 hours
    Result: Induced programmed cell death.

    Cell Cycle Analysis[1]

    Cell Line: MCF-7, MDA-MB-231 cells
    Concentration: 20 nM
    Incubation Time: 48 hours
    Result: >60% of MCF-7 cells and 50% of MDA-MB-231 cells were in the G2/M phase following 24 h treament.

    Western Blot Analysis[1]

    Cell Line: MCF-7 cells (harboring wild-type p53)
    Concentration: 20 nM
    Incubation Time: 48 hours
    Result: Induced a consistent increase in the level of p53.
    In Vivo

    Paclitaxel (1-20 mg/kg; i.p.; 1 time/2 days for five cycles) obviously induces liver metastases at the low-Paclitaxel group with little influence on primary tumor growth[3].

    Animal Model: MDA-231 xenograft-bearing mice[3]
    Dosage: 1, 20 mg/kg
    Administration: Intraperitoneal injection; five cycles (1 time/2 days)
    Result: Liver metastases were obviously induced in the low-PTX (1 mg/kg) group with little influence on primary tumor growth compared with high-PTX group.
    Clinical Trial
    Molecular Weight

    853.91

    Formula

    C₄₇H₅₁NO₁₄

    CAS No.

    33069-62-4

    SMILES

    O=C(C1=CC=CC=C1)N[[email protected]@H](C2=CC=CC=C2)[[email protected]](C(O[[email protected]@H]3C(C)=C([[email protected]@H](OC(C)=O)C([[email protected]@]4(C)[[email protected]]([[email protected]@](CO5)(OC(C)=O)[[email protected]@]5([H])C[[email protected]@H]4O)([H])[[email protected]@H]6OC(C7=CC=CC=C7)=O)=O)C(C)(C)[[email protected]@]6(O)C3)=O)O

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    4°C, protect from light

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 31 mg/mL (36.30 mM)

    H2O : < 0.1 mg/mL (insoluble)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.1711 mL 5.8554 mL 11.7108 mL
    5 mM 0.2342 mL 1.1711 mL 2.3422 mL
    10 mM 0.1171 mL 0.5855 mL 1.1711 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (2.93 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (2.93 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References

    Purity: 99.97%

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    KeyWords:

    Paclitaxel | Taxol | Microtubule/Tubulin | ADC Cytotoxin | Autophagy | Inhibitor | inhibitor | inhibit

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    Product name:
    Paclitaxel
    Cat. No.:
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