1. Signaling Pathways
  2. Vitamin D Related
  3. VD/VDR


Vitamin D is a secosteroidalprohormone, it can be synthesized at sufficient levels in skin, given adequate skin exposure to UV B radiation from sunlight. Vitamin D modulates its biological effects by directly regulating target gene expression through the Vitamin D receptor (VDR), a ligand-regulated transcription factor and a member of the nuclear receptor superfamily. Whether synthesized in the skin or ingested, vitamin D requires two hydroxylation steps to become the biologically active hormone, 1,25-dyhydroxyvitamin D3 [1,25(OH)2D3], a form that signals through the VDR. The hormone-bound VDR modulates target gene transcription in response to vitamin D. VDR acts as a master transcriptional regulator of autophagy. Activation of the VDR by vitamin D induces autophagy and an autophagic transcriptional signature in breast cancer (BC) cells.

There are 2 forms of vitamin D. Vitamin D2 (ergocalciferol) comes from irradiation of the yeast and plant sterol ergosterol, and vitamin D3 (cholecalciferol) is found in oily fish and cod liver oil and is made in the skin. Vitamin D represents vitamin D2 and vitamin D3.

Topical agents containing active vitamin D3 (calcitriol, 1α, 25- dihydroxyvitaminD3, VD3) analogues such as Tacalcitol, Calcipotriol and Maxacalcitol are widely used for psoriasis therapy.

VD/VDR Related Products (55):

Cat. No. Product Name Effect Purity
  • HY-10002
    Calcitriol Agonist 99.81%
    Calcitriol is the most active metabolite of vitamin D and also a vitamin D receptor (VDR) agonist.
  • HY-10001
    Calcipotriol Chemical 99.77%
    Calcipotriol is a synthetic VitD3 analogue with a high affinity for the vitamin D receptor.
  • HY-32339
    Maxacalcitol Activator 99.71%
    Maxacalcitol (22-Oxacalcitriol) is non-calcemic vitamin D3 analog and ligand of VDR-like receptors.
  • HY-15398
    Cholecalciferol Activator >98.0%
    Cholecalciferol(Vitamin D3) is a naturally occuring form of vitamin D; Reported that upon metabolic activation, Cholecalciferol induces cell differentiation and prevents proliferation of cancer cells.
  • HY-50919
    Paricalcitol Agonist 99.95%
    Paricalcitol is a vitamin D receptor agonist, used for the prevention and treatment of secondary hyperparathyroidism (excessive secretion of parathyroid hormone) associated with chronic renal failure.
  • HY-114310
    VDR agonist 1 Agonist
    VDR agonist 1 (compound 28) is a nonsteroidal Vitamin D receptor (VDR) agonist, with an IC50 of 690 nM in MCF-7 cells. VDR agonist 1 arrests the cell cycle through the up-regulation of p21 and p27, promotes apoptosis by increasing the expression of BAX and decrease the expression of Bcl-2.
  • HY-10001A
    Calcipotriol monohydrate Activator 99.75%
    Calcipotriol monohydrate is a synthetic VitD3 analogue with a high affinity for the vitamin D receptor.
  • HY-32351A
    Calcifediol monohydrate 99.89%
    Calcifediol (monohydrate) is a major circulating metabolite of vitamin D3, acting as a competitive inhibitor with an apparent Ki of 3.9 μM, suppresses PTH secretion and mRNA (ED50=2 nM).
  • HY-15254
    3-O-(2-Aminoethyl)-25-hydroxyvitamin D3 Chemical 98.71%
    3-O-(2-Aminoethyl)-25-hydroxyvitamin D3 is a Vitamin D3 derivative.
  • HY-32350
    Ercalcitriol Activator 99.33%
    Ercalcitriol (1α,25-Dihydroxy Vitamin D2) is an active metabolite of vitamin D2.
  • HY-32341
    Seocalcitol Agonist 98.85%
    Seocalcitol is a vitamin D analog, binds vitamin D receptor protein from human osteosarcoma MG-63 cells with Kd of 0.27 nM.
  • HY-32349
    Ercalcidiol Modulator 98.93%
    Ercalcidiol is a metabolite of vitamin D2, is regarded as an indicator of vitamin D nutritional status.
  • HY-76542
    Vitamin D2 Activator 99.53%
    Vitamin D2 (Ergocalciferol) is a form of vitamin D, used as a vitamin D supplement.
  • HY-15157
    Calcitetrol Activator
    Calcitetrol(1α, 24, 25-Trihydroxy VD3) is the hormonally active form of vitamin D with three hydroxyl groups.
  • HY-76915
    24, 25-Dihydroxy VD3 Activator 98.20%
    24, 25-Dihydroxy VD3 is a compound which is closely related to 1,25-dihydroxyvitamin D3, the active form of vitamin D3, but like vitamin D3 itself and 25-hydroxyvitamin D3 is inactive as a hormone both in vitro and in vivo.
  • HY-15830
    25,26-Dihydroxyvitamin D3 Activator 98.08%
    25,26-Dihydroxyvitamin D3(25,26-dihydroxycholecalciferol) is a metabolite of vitamin D3 with intestinal calcium transport activity.
  • HY-32343
    Secalciferol Activator 98.58%
    Secalciferol is a metabolite of Vitamin D, a possibly anti-inflammatory steroid which is involved in bone ossification.
  • HY-76801
    24, 25-Dihydroxy VD2 Activator 99.79%
    24, 25-Dihydroxy VD2 is a hydroxylated metabolite of Vitamin D2; a synthetic analog of Vitamin D.
  • HY-32348
    Doxercalciferol Activator 99.85%
    Doxercalciferol is a Vitamin D2 analog, acts as an activator of Vitamin D receptor, and prevent renal disease.
  • HY-32337
    Tacalcitol Activator 98.88%
    Tacalcitol (1,24(R)-Dihydroxyvitamin D3; 1.alpha.,24R-Dihydroxyvitamin D3) promotes normal bone development by regulating calcium.
Isoform Specific Products

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