G-Protein-Coupled Receptors (GPCRs)
G Protein-Coupled Receptors (GPCRs), also called 7TM receptors, are the largest and most important integral membrane protein families, which mediate cellular responses to most hormones, metabolites, cytokines, and neurotransmitters, and therefore serve as “fruitful targets” for drug discovery. G Protein Coupled Receptors (GPCRs) perceive many extracellular signals and transduce them to heterotrimeric G proteins, which further transduce these signals intracellular to appropriate downstream effectors and thereby play an important role in various signaling pathways. GPCRs are categorized into six classes based on sequence and function: rhodopsin-like receptors (family A), secretin-like (family B), glutamate (family C), fungal mating pheromone receptors (Class D), cAMP receptors (Class E) and frizzled/smoothened (Class F). GPCRs in vertebrates are commonly divided in to rhodopsin (family A), secretin (family B), glutamate (family C), adhesion and Frizzled/Taste2, based on an alternative classification system (GRAFS).
- Chemokine Receptor (33)
- Frizzled (23)
- Glucagon Receptor (15)
- Metabotropic Glutamate Receptors (8)
- Endothelin Receptor (7)
- Adhesion GPCRs (7)
- Protease-activated Receptor (4)
- Cannabinoid Receptor (4)
- Somatostatin Receptor (3)
- TSH Receptor (2)
- Adenosine Receptor (2)
- GPR49 (2)
- Muscarinic Acetylcholine Receptor (1)
- FSH Receptor (1)
- GPR37 (1)
- CT Receptor (Calcitonin Receptor) (1)
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G-Protein-Coupled Receptors (GPCRs) Recombinant Proteins (136)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
