Angiotensinogen
Angiotensinogen (AGT, SERPINA8) is the substrate-forming member of the serpin superfamily: its N-terminal region is cleaved by the renal enzyme renin to release angiotensin I, the origin of the entire renin-angiotensin cascade that controls blood pressure, fluid balance, and vascular tone. Synthesized predominantly by hepatocytes and secreted in large amounts into plasma, angiotensinogen levels are upregulated by estrogens, glucocorticoids, and angiotensin II itself, and AGT gene variants are associated with hypertension and preeclampsia. Local production also occurs in kidney, heart, brain, and adipose tissue. Recombinant angiotensinogen is a key reagent for renin activity assays and cardiovascular drug development targeting the RAAS axis.
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Angiotensinogen Recombinant Proteins (4)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
