TREM-1/CD354
TREM-1, the CD354 antigen, is an activating immunoglobulin-like receptor expressed on neutrophils, monocytes and macrophages. Lacking a cytoplasmic signaling motif of its own, it associates through a charged transmembrane residue with the DAP12 and FcR gamma adapters, amplifying TLR- and NOD-like receptor-driven responses to microbial challenge. TREM-1 expression is strongly induced during bacterial and fungal infections, and its soluble ectodomain is a validated biomarker for distinguishing bacterial from non-bacterial inflammatory disease. Pharmacological inhibition of TREM-1, including the peptide nangibotide, has been tested clinically in septic shock, positioning the receptor as a central node of innate immune amplification.
-
TREM-1/CD354 Recombinant Proteins (4)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
