TREM-1 Protein, Cynomolgus (HEK293, His)

The TREM-1 protein is a cell surface receptor that critically regulates innate and adaptive immunity by enhancing inflammatory responses. TREM-1 plays a crucial role in acute and chronic inflammatory diseases, acting as a decoy receptor to balance its pro-inflammatory effects. TREM-1 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived TREM-1 protein, expressed by HEK293 , with C-8*His labeled tag.

TREM-1 protein, as a cell surface receptor, potentially participates in innate and adaptive immune responses. Following phosphorylation, it interacts with PTPN6 and PTPN11, indicating its role in signaling pathways linked to these phosphatases. This interaction highlights the regulatory mechanisms TREM-1 may contribute to in modulating the immune system.

Cynomolgus

HEK293

C-8*His

A0A2K5VHG8/XP_005553111 (T21-P201)

102129811  [NCBI]

Extracellular Domain

TTELTEEKYEYKEGQTLEVKCDYALEKYANSRKAWQKMEGKMPKILAKTERPSENSHPVQVGRITLEDYPDHGLLQVRMTNLQVEDSGLYQCVIYQHPKESHVLFNPICLVVTKGSSGTPGSSENSTQNVYRTPSTTAKALGPRYTSPRTVTQAPPESTVVVSTPGSEINLTNVTDIIRVP

Approximately 45-60 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.

≥ 95%, as determined by Bis-Tris PAGE.

Lyophilized powder

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4, 8% trehalose.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.