1. Signaling Pathways
  2. GPCR/G Protein
  3. P2Y Receptor

P2Y Receptor

P2Y receptors are a family of purinergic G protein-coupled receptors, stimulated by nucleotides such as ATP, ADP, UTP, UDP and UDP-glucose. To date, 12 P2Y receptors have been cloned in humans: P2Y1, P2Y2, P2Y4, P2Y5, P2Y6, P2Y8, P2Y9, P2Y10, P2Y11, P2Y12, P2Y13 and P2Y14. P2Y receptors are present in almost all human tissues where they exert various biological functions based on their G-protein coupling. P2Y2 is a potential drug target for treating cystic fibrosis. P2Y11 is a regulator of immune response, and a common polymorphism carried by almost 20% of North European caucasians give increased risk of myocardial infarction, making P2Y11 an interesting drug target candidate for treatment of myocardial infarction. P2Y12 is the target of the anti-platelet drug clopidogrel and other thienopyridines.

P2Y Receptor Related Products (24):

Cat. No. Product Name Effect Purity
  • HY-B0879A
    Suramin sodium salt Inhibitor 99.93%
    Suramin sodium salt (Suramin hexasodium salt), a polysulfonated naphthylurea, is a potent competitive DNA topoisomerase II inhibitor with an IC50 of 5 μM. Suramin sodium salt inhibits IL-4 with an IC50 of 55-70 μM. Suramin sodium salt has antiproliferative, anticancer, and anti-HIV activities and prevents binding of a variety of growth factors to their respective receptors.
  • HY-17459
    Clopidogrel hydrogen sulfate Inhibitor
    Clopidogrel hydrogen sulfate is an antiplatelet agent which works by blocking platelets from sticking together and prevents them from forming harmful clots.
  • HY-10064
    Ticagrelor Antagonist 99.98%
    Ticagrelor (AZD6140) is a reversible oral P2Y12 receptor antagonist for the treatment of platelet aggregation.
  • HY-B0606
    Diquafosol tetrasodium Agonist 99.93%
    Diquafosol tetrasodium is a P2Y2 receptor agonist that stimulates fluid and mucin secretion on the ocular surface, as a topical treatment of dry eye disease.
  • HY-13104
    MRS 2578 Antagonist
    MRS 2578 is a selective and potent P2Y6 receptor antagonist with IC50s of 37 nM (human) and 98 nM (rat). MRS 2578 exhibits insignificant activity at P2Y1, P2Y2, P2Y4, and P2Y11 receptors.
  • HY-111557
    YM-254890 Inhibitor
    YM-254890 is a selective Gαq/11 protein inhibitor isolated from Chromobacterium sp. YM-254890 shows no inhibition of other G protein subtypes. YM-254890 inhibits platelet aggregation induced by ADP by blocking the P2Y1 signal transduction pathway, with an IC50 value below 0.6 μM.
  • HY-108672
    NF157 Antagonist
    NF157 is a highly selective nanomolar P2Y11 antagonist with a pKi of 7.35. The IC50s are 463 nM, 1811 µM, 170 µM for P2Y11 (Ki=44.3 nM), P2Y1 (Ki=187 µM), P2Y2 (Ki=28.9 µM), respectively. NF157, significantly reduces expression of metalloproteinase (MMP)-3, MMP-13, can be used in the treatment of osteoarthritis (OA).
  • HY-110322A
    PPTN Antagonist
    PPTN is a potent, high-affinity, competitive and highly selective P2Y14 receptor antagonist with a KB value of 434 pM. Anti-inflammatory and immune activity.
  • HY-N7032
    Uridine 5′-diphosphoglucose disodium salt Agonist 99.52%
    Uridine 5′-diphosphoglucose disodium salt (UDP-D-Glucose disodium salt) is the precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and in some microorganisms. Uridine-5′-diphosphoglucose is an agonist of the P2Y14 receptor, a neuroimmune system GPCR.
  • HY-13831
    BPTU Antagonist 98.03%
    BPTU is a novel P2Y1 allosteric antagonist.
  • HY-15799
    AZD1283 Antagonist 99.11%
    AZD1283 is a potent antagonist of the P2Y12 receptor with EC50 of 3.0 ug/kg/min, TI >10; with binding IC50 of 11 nM.
  • HY-15284
    Prasugrel Inhibitor >98.0%
    Prasugrel (PCR 4099) is a platelet inhibitor with IC50 value of 1.8 μM.
  • HY-15876
    Clopidogrel thiolactone Inhibitor >98.0%
    Clopidogrel thiolactone is a P2Y12 receptor inhibitor, is a potent antiplatelet agent.
  • HY-18775
    N6-(4-Hydroxybenzyl)adenosine Inhibitor 99.66%
    N6-(4-Hydroxybenzyl)adenosine is a inhibitor of platelet aggregation induced in vitro by collagen and their activity range was demonstrated (IC50: 6.77-141 μM).
  • HY-15284A
    Prasugrel hydrochloride Inhibitor 99.57%
    Prasugrel hydrochloride (PCR 4099 hydrochloride) is a platelet inhibitor with IC50 value of 1.8 μM.
  • HY-B0879
    Suramin Inhibitor
    Suramin, a polysulfonated naphthylurea, is a potent competitive DNA topoisomerase II inhibitor with an IC50 of 5 μM. Suramin inhibits IL-4 with an IC50 of 55-70 μM. Suramin has antiproliferative, anticancer, and anti-HIV activities and prevents binding of a variety of growth factors to their respective receptors.
  • HY-15283
    Clopidogrel Inhibitor
    Clopidogrel is a well-known and orally active platelet inhibitor that targets P2Y12 receptor. Clopidogrel is used to inhibit blood clots in coronary artery disease, peripheral vascular disease, and cerebrovascular disease.
  • HY-111755
    Oral antiplatelet agent 1 Antagonist
    Oral antiplatelet agent 1 is a potent antiplatelet agent with an IC50 of 2.94 μM in vitro as well as antithrombotic efficacy in a rat model. P2Y receptor antagonist.
  • HY-118284
    Vicagrel Inhibitor 98.55%
    Vicagrel, an acetate derivative of Clopidogrel, is a P2Y12 platelet inhibitor potentially for the treatment of thrombosis, the substrate of carboxylesterase 2 (CES2). Vicagrel demonstrates a favorable safety profile and excellent anti-platelet activity, which could be an anti-platelet drug and for the unmet medical needs of cardiovascular diseases.
  • HY-108661
    NF546 Agonist
    NF546 is a selective non-nucleotide P2Y11 agonist with a pEC50 of 6.27. NF546 stimulates release of interleukin-8 from human monocyte-derived dendritic cells.
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