1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Phospholipase

Phospholipase

Phospholipase is a member of a very complex group of enzymes that break down phospholipids into fatty acids and other compounds. Phospholipases are defined by the enzymatic reaction they catalyze. The classes are phospholipase A, which has members A1 and A2; phospholipase B, which can carry out the reactions of both A1 and A2; phospholipase C; and phospholipase D.

Phospholipase A2 (PLA2) catalyses the hydrolysis of the sn-2 position of glycerophospholipids to yield fatty acids and lysophospholipids. Phospholipase C (PLC) converts phosphatidylinositol 4,5-bisphosphate (PIP2) to inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). DAG and IP3 each control diverse cellular processes and are also substrates for synthesis of other important signaling molecules. PLC is thus central to many important interlocking regulatory networks. Phospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membrane trafficking, actin cytoskeleton remodeling, cell proliferation and cell survival.

Phospholipase Isoform Specific Products:

  • Phospholipase A

  • PLD

Phospholipase Related Products (31):

Cat. No. Product Name Effect Purity
  • HY-13419
    U-73122 Inhibitor 98.17%
    U-73122 is a phospholipase C (PLC) and 5-LO (5-lipoxygenase) inhibitor with an IC50of 1-2.1 µM for PLC.
  • HY-70072
    D609 Inhibitor >98.0%
    D609 is a selective competitive inhibitor of phosphatidyl choline-specific phospholipase C (PC-PLC), with Ki of 6.4 μM.
  • HY-P0233
    Melittin Activator
    Melittin is a PLA2 activator, stimulates the activity of the low molecular weight PLA2, while it does not the increase activity of the high molecular weight PLA2.
  • HY-13735A
    Quinacrine dihydrochloride Inhibitor 98.05%
    Quinacrine dihydrochloride (Mepacrine dihydrochloride) is a fluorescent probe for the conformational transitions of the cholinergic receptor protein.
  • HY-10521
    Darapladib Inhibitor 99.95%
    Darapladib is a potent inhibitor of lipoprotein-associated phospholipase A2 (Lp-PLA2) with IC50 of 0.25 nM.
  • HY-111919
    3-Nitrocoumarin Inhibitor 100%
    3-Nitrocoumarin (3-NC) is a potent and selective Phospholipase C-γ (PLC-γ) inhibitor.
  • HY-108630
    U-73343 Inhibitor >99.0%
    U-73343, an inhibitor of PLC (putative phospholipase C)-dependent processes, is an analog of U-73122 and can be used as a negative control.
  • HY-N7036
    Rhamnetin Inhibitor
    Rhamnetin is a quercetin derivative found in Coriandrum sativum, inhibits secretory phospholipase A2, with antioxidant and anti-inflammatory activity.
  • HY-13402
    Varespladib Inhibitor 98.03%
    Varespladib (LY315920) is a potent and selective group IIA, secretory phospholipase A2 (sPLA2) inhibitor with an IC50 of 9 nM. Varespladib exhibits the significant inhibitory effect on sPLA2 activity in serum from various species including rat, rabbit, guinea pig and human with IC50s of 8.1 nM, 5.0 nM, 3.2 nM and 6.2 nM, respectively.
  • HY-100736
    ML348 Inhibitor 99.88%
    ML348 is a selective and reversible lysophospholipase 1 (LYPLA1) inhibitor with an IC50 of 210 nM, and barely inhibits LYPLA2.
  • HY-12807
    FIPI Inhibitor 99.49%
    FIPI is a derivative of halopemide which potently inhibits both PLD1 and PLD2 with IC50s of 25 nM and 20 nM, respectively.
  • HY-N0134
    Tanshinone I Inhibitor >98.0%
    Tanshinone I is an inhibitor of type IIA human recombinant sPLA2 (IC50=11 μM) and rabbit recombinant cPLA2 (IC50=82 μM).
  • HY-103334
    MAFP Inhibitor >98.0%
    MAFP (Methyl Arachidonyl Fluorophosphonate) is an selective, active-site directed and irreversible inhibitor of cPLA2 and iPLA2. MAFP is also a potent irreversible inhibitor of anandamide amidase.
  • HY-100737
    ML349 Inhibitor 98.90%
    ML349 is a potent and specific acyl protein thioesterase 2 (APT-2) inhibitor with a Ki of 120 nM. ML349 is also an inhibitor of LYPLA2 with an IC50 of 144 nM.
  • HY-118628
    N-(p-amylcinnamoyl) Anthranilic Acid Inhibitor 98.81%
    N-(p-amylcinnamoyl) Anthranilic Acid (ACA) is a broad spectrum Phospholipase A2 (PLA2) inhibitor and TRP channel blocker. N-(p-amylcinnamoyl) Anthranilic Acid (ACA) is also an effective reversible inhibitor of calcium-activated chloride channels, has potential to treat arrhythmia.
  • HY-18522
    AA26-9 Inhibitor 99.78%
    AA26-9 is a potent and broad spectrum serine hydrolase inhibitor.
  • HY-19757
    Lp-PLA2 -IN-1 Inhibitor 99.46%
    Lp-PLA2 -IN-1 inhibit Lp-PLA2 activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases associated with the activity of Lp-PLA2, for example atherosclerosis, Alzheimer's disease.
  • HY-B0653A
    Levobupivacaine hydrochloride Inhibitor 99.85%
    Levobupivacaine hydrochloride is a local anaesthetic compound belonging to the amino amide group; long-acting local anesthetic.
  • HY-10801
    CAY10650 Inhibitor >98.0%
    CAY10650 is a highly potent cytosolic phospholipase A2α (cPLA2α) inhibitor with an IC 50 value of 12 nM.
  • HY-103097
    ST271 Inhibitor 98.23%
    ST271 is a potent inhibitor of protein tyrosine kinase (PTK), inhibits phospholipase D activation stimulated by fMet-Leu-Phe and PAF, with IC50s of 6.7 and 9 μM, respectively.
Isoform Specific Products

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