1. Membrane Transporter/Ion Channel
    Autophagy
  2. Proton Pump
    Autophagy
  3. Omeprazole

Omeprazole (Synonyms: H 16868)

Cat. No.: HY-B0113 Purity: 97.06%
Handling Instructions

Omeprazole (H 16868) is a proton pump inhibitor used in the treatment of dyspepsia.

For research use only. We do not sell to patients.

Omeprazole Chemical Structure

Omeprazole Chemical Structure

CAS No. : 73590-58-6

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10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
100 mg USD 60 In-stock
Estimated Time of Arrival: December 31
500 mg USD 120 In-stock
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Description

Omeprazole (H 16868) is a proton pump inhibitor used in the treatment of dyspepsia.

IC50 & Target

Proton Pump[1].

In Vitro

Omeprazole (H 16868) is a proton pump inhibitor used in the treatment of dyspepsia, peptic ulcer disease, gastroesophageal reflux disease, laryngopharyngeal reflux, and Zollinger-Ellison syndrome. Omeprazole (H 16868) virtually eliminated intragastric acidity in all patients: the median 24 hour intragastric pH rose from 1.4 to 5.3 and the mean hourly hydrogen ion activity fell from 38.50 to 1.95 mmol(mEq)/1 (p less than 0.001). This inhibition of 24 hour intragastric acidity is more profound than that previously reported with either cimetidine 1 g daily or ranitidine 300 mg daily[1]. The pharmacokinetics of omeprazole were studied in a group of healthy male subjects after single and repeated oral doses of 30 and 60 mg. Absorption of Omeprazole (H 16868) from its enteric-coated formulation was unpredictable. There was a highly significant increase in the area under the plasma concentration time curve (AUC) after repeated dosing. Omeprazole (H 16868) increases its own relative availability following repeated dosing. This may be due to inhibition of gastric acid secretion by omeprazole which is an acid-labile compound[2].

Clinical Trial
Molecular Weight

345.42

Formula

C₁₇H₁₉N₃O₃S

CAS No.

73590-58-6

SMILES

O=S(C1=NC2=CC=C(OC)C=C2N1)CC3=NC=C(C)C(OC)=C3C

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (289.50 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8950 mL 14.4751 mL 28.9503 mL
5 mM 0.5790 mL 2.8950 mL 5.7901 mL
10 mM 0.2895 mL 1.4475 mL 2.8950 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.24 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.24 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.24 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Omeprazole
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