Musk
MuSK (muscle-specific kinase) is a single-member receptor tyrosine kinase family essential for neuromuscular junction formation. Its extracellular region contains three immunoglobulin-like domains and a frizzled-like cysteine-rich domain. In developing muscle, the heparan-sulfate proteoglycan agrin released from motor neuron terminals binds LRP4, which recruits and activates MuSK, triggering a signaling cascade with Dok7 that leads to rapsyn-mediated clustering of acetylcholine receptors at the synaptic membrane. MuSK also specifies postsynaptic differentiation and retrogradely signals to presynaptic terminals. Autoantibodies against MuSK cause a severe form of myasthenia gravis with prominent bulbar weakness, distinguishable from classic acetylcholine receptor antibody disease, and treated with complement inhibitors and B-cell-directed therapies.
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Musk Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
