1. Signaling Pathways
  2. Immunology/Inflammation
  3. STING


STING (Stimulator of Interferon Genes) is an endoplasmic-reticulum (ER)-membrane protein that induced innate immunity for anti-microbial by activating the expression of type I IFN and other inflammatory cytokines. The activation of STING is mediated by cyclic dinucleotides (cAMP, cGMP and cGAMP) produced by DNA sensors (such as cGAS) from cytosolic DNA.

As reported, cGAS-STING pathway can be activated not only by viral and bacterial DNA, but also self-DNA such as tumor-derived DNA. Hence, activating of STING will induce tumor cell senescence, inflammation, and anti-tumor immunity and play important roles in tumor immunity. Small molecules capable of triggering STING are effective at blocking virus replication, enhancing vaccine efficacy, and facilitating immune response to cancer cells.

STING Related Products (26):

Cat. No. Product Name Effect Purity
  • HY-100941
    CCCP Inhibitor 99.83%
    CCCP is an oxidative phosphorylation (OXPHOS) uncoupler. CCCP induces activation of PINK1 leading to Parkin Ser65 phosphorylation.
  • HY-10964
    Vadimezan Agonist 99.81%
    Vadimezan (DMXAA; ASA-404), the tumor vascular disrupting agent (tumor-VDA), is a murine agonist of the stimulator of interferon genes (STING) and also a potent inducer of type I IFNs and other cytokines. Vadimezan has anti-influenza virus H1N1-PR8 activities.
  • HY-112906
    C-176 Inhibitor 99.22%
    C-176 is a strong and covalent mouse STING inhibitor.
  • HY-112693
    H-151 Antagonist 99.86%
    H-151 is a potent, selective and covalent antagonist of STING that has noteworthy inhibitory activity both in cells and in vivo. H-151 reduces TBK1 phosphorylation and suppresses STING palmitoylatio. H-151 can be used for the research of autoinflammatory disease.
  • HY-12885
    ADU-S100 Activator 99.53%
    ADU-S100 (MIW815), an activator of stimulator of interferon genes (STING), leads to potent and systemic tumor regression and immunity.
  • HY-131454
    SR-717 Agonist 99.75%
    SR-717 is a non-nucleotide STING agonist with EC50s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. SR-717 is a stable cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) mimetic. Antitumor activity.
  • HY-136927
    MSA-2 Agonist 98.79%
    MSA-2, a potent and orally available non-nucleotide STING agonist, has EC50s of 8.3 and 24 μM for human STING isoforms WT and HAQ, respectively. MSA-2 shows antitumor activity and stimulates interferon-β secretion in tumors, induces tumor regression with durable antitumor immunity, and synergizes with anti-PD-1 in syngeneic mouse tumor models.
  • HY-114399
    STING ligand-1
    STING ligand-1 is a lead STING ligand with an IC50 of 68 nM for HAQ STING.
  • HY-112921B
    diABZI STING agonist-1 trihydrochloride Agonist 99.89%
    diABZI STING agonist-1 (trihydrochloride) is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively.
  • HY-12885B
    ADU-S100 ammonium salt Activator 99.44%
    ADU-S100 ammonium salt (MIW815 ammonium salt), an activator of stimulator of interferon genes (STING), leads to potent and systemic tumor regression and immunity.
  • HY-12212
    Omaveloxolone Inhibitor 99.40%
    Omaveloxolone (RTA 408) is an antioxidant inflammation modulator (AIM), which activates Nrf2 and suppresses nitric oxide (NO). Omaveloxolone attenuates osteoclastogenesis by inhibiting STING dependent NF-κb signaling.
  • HY-12512
    cGAMP Activator 98.56%
    cGAMP (Cyclic GMP-AMP; 3',3'-cGAMP) is an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA; STING ligand.
  • HY-100564A
    2',3'-cGAMP sodium Activator >99.0%
    2',3'-cGAMP sodium (2'-3'-cyclic GMP-AMP sodium) is a endogenous cGAMP in mammalian cells. 2',3'-cGAMP sodium binds to STING with a high affinity and is a potent inducer of interferon-β (IFNβ). 2',3'-cGAMP sodium is produced in mammalian cells in response to DNA in the cytoplasm.
  • HY-107780
    Cyclic-di-GMP Activator 99.26%
    Cyclic-di-GMP (c-di-GMP) is a STING activator and a ubiquitous second messenger that regulates biofilm formation, motility, and virulence in diverse bacterial species.
  • HY-12885A
    ADU-S100 disodium salt Activator 98.83%
    ADU-S100 disodium salt (MIW815 disodium salt) is an activator of stimulator of interferon genes (STING).
  • HY-12326
    c-di-AMP Agonist 99.29%
    c-di-AMP (Cyclic diadenylate) is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP (Cyclic diadenylate) is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP (Cyclic diadenylate) acts as a potent mucosal adjuvant stimulating both humoral and cellular responses.
  • HY-103665
    STING agonist-3 Agonist 99.96%
    STING agonist-3, extracted from patent WO2017175147A1 (example 10), is a selective and non-nucleotide small-molecule STING agonist with a pEC50 and pIC50 of 7.5 and 9.5, respectively. STING agonist-3 has durable anti-tumor effect and tremendous potential to improve treatment of cancer.
  • HY-19711
    STING agonist-1 Agonist 99.54%
    STING agonist-1 (G10) is human-specific STING agonist that elicits antiviral activity against emerging Alphaviruses. G10 potently blocks replication of Alphavirus species Venezuelan Equine Encephalitis Virus (VEEV) with IC90 of 24.57 μM.
  • HY-123963
    C-178 Inhibitor 99.90%
    C-178 is a potent and selective covalent inhibitor of STING. C-178 binds to Cys91 and suppresses the STING responses elicited by distinct bona fide activators in mouse but not human.
  • HY-123943
    STING agonist-4 Agonist 99.52%
    STING agonist-4 is an stimulator of Interferon Genes (STING) receptor agonist with an apparent inhibitory constant (IC50) of 20 nM. STING agonist-4 is a two symmetry-related amidobenzimidazole (ABZI)-based compound to create linked ABZIs (diABZIs) with enhanced binding to STING and cellular function.
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