1. Immunology/Inflammation
  2. STING

STING

STING (Stimulator of Interferon Genes) is a transmembrane protein localized to the endoplasmic reticulum that undergoes a conformational change in response to direct binding of cyclic dinucleotides (CDNs), resulting in a downstream signaling cascade involving TBK1 activation, IRF-3 phosphorylation, and production of IFN-β and other cytokines.

STING is a pattern recognition receptor of cyclic dinucleotides as well as an innate immune adaptor protein that enables signaling from cytoplasmic receptors to the transcription factor interferon regulatory factor 3. Initiation of these pathways leads to the expression of type I interferons and proteins associated with antiviral and antitumor immunity. Small molecules capable of triggering STING-dependent cellular processes are effective at blocking virus replication, enhancing vaccine efficacy, and facilitating immune response to cancer cells.

STING Related Products (13):

Cat. No. Product Name Effect Purity
  • HY-100941
    CCCP Inhibitor 99.83%
    CCCP is an oxidative phosphorylation uncoupler.
  • HY-12885B
    ADU-S100 ammonium salt Activator 99.23%
    ADU-S100 ammonium salt is an activator of stimulator of interferon genes (STING).
  • HY-10964
    Vadimezan Agonist 99.81%
    Vadimezan (ASA-404; DMXAA), the vascular disrupting agent, is a murine agonist of the stimulator of interferon genes (STING) and also a potent inducer of type I IFNs and other cytokines.
  • HY-12885
    ADU-S100 Activator 99.23%
    ADU-S100 is an inducer of STING (stimulator of interferon genes). ADU-S100 has enhanced binding affinity to STING and activate all known human STING alleles.
  • HY-112906
    C-176 Inhibitor >98.0%
    C-176 is a strong and covalent mouse STING inhibitor.
  • HY-112921B
    diABZI STING agonist-1 trihydrochloride Agonist
    diABZI STING agonist-1 (trihydrochloride) is a selective stimulator of interferon genes (STING) receptor agonist.
  • HY-112921
    diABZI STING agonist-1 Tautomerism Agonist
    diABZI STING agonist-1 (Tautomerism) is a selective stimulator of interferon genes (STING) receptor agonist, with an EC50s of 130 for human PBMCs.
  • HY-19711
    STING agonist-1 Agonist 99.06%
    STING agonist-1 (G10) is a novel human-specific STING agonist that elicits antiviral activity against emerging Alphaviruses. G10 potently blocks replication of Alphavirus species Venezuelan Equine Encephalitis Virus (VEEV) (IC90 = 24.57 μM).
  • HY-107780
    Cyclic-di-GMP Agonist 99.26%
    Cyclic-di-GMP is a STING agonist and a ubiquitous second messenger that regulates biofilm formation, motility, and virulence in diverse bacterial species.
  • HY-12512
    cGAMP Activator 98.56%
    cGAMP(Cyclic GMP-AMP) is an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA; STING ligand.
  • HY-112921A
    diABZI STING agonist-1 Agonist
    diABZI STING agonist-1 is a selective stimulator of interferon genes (STING) receptor agonist.
  • HY-114399
    STING ligand-1
    STING ligand-1 is a lead STING ligand with an IC50 of 68 nM for HAQ STING.
  • HY-112951
    ChX710
    ChX710 could prime the type I interferon response to cytosolic DNA, which induces the ISRE promoter sequence, specific cellular Interferon-Stimulated Genes (ISGs), and the phosphorylation of Interferon Regulatory Factor (IRF) 3.
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