1. Immunology/Inflammation
  2. STING

STING

STING (Stimulator of Interferon Genes) is a transmembrane protein localized to the endoplasmic reticulum that undergoes a conformational change in response to direct binding of cyclic dinucleotides (CDNs), resulting in a downstream signaling cascade involving TBK1 activation, IRF-3 phosphorylation, and production of IFN-β and other cytokines.

STING is a pattern recognition receptor of cyclic dinucleotides as well as an innate immune adaptor protein that enables signaling from cytoplasmic receptors to the transcription factor interferon regulatory factor 3. Initiation of these pathways leads to the expression of type I interferons and proteins associated with antiviral and antitumor immunity. Small molecules capable of triggering STING-dependent cellular processes are effective at blocking virus replication, enhancing vaccine efficacy, and facilitating immune response to cancer cells.

STING Related Products (4):

Cat. No. Product Name Effect Purity
  • HY-19711
    STING agonist-1 Agonist 99.06%
    STING agonist-1 (G10) is a novel human-specific STING agonist that elicits antiviral activity against emerging Alphaviruses. G10 potently blocks replication of Alphavirus species Venezuelan Equine Encephalitis Virus (VEEV) (IC90 = 24.57 μM).
  • HY-12885B
    ML RR-S2 CDA ammonium salt Activator 99.93%
    ML RR-S2 CDA ammonium salt is an inducer of STING (stimulator of interferon genes).
  • HY-12885
    ML RR-S2 CDA Activator
    ML RR-S2 CDA (STING-Inducer-1) is a highly active cyclic-di-nucleotide immune stimulators that activate DCs via the cytoplamtic receptor STING (Stimulator of Interferon Genes).
  • HY-12512
    cGAMP Activator
    cGAMP(Cyclic GMP-AMP) is an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA; STING ligand.