1. Immunology/Inflammation
  2. STING

STING

STING (Stimulator of Interferon Genes) is a transmembrane protein localized to the endoplasmic reticulum that undergoes a conformational change in response to direct binding of cyclic dinucleotides (CDNs), resulting in a downstream signaling cascade involving TBK1 activation, IRF-3 phosphorylation, and production of IFN-β and other cytokines.

STING is a pattern recognition receptor of cyclic dinucleotides as well as an innate immune adaptor protein that enables signaling from cytoplasmic receptors to the transcription factor interferon regulatory factor 3. Initiation of these pathways leads to the expression of type I interferons and proteins associated with antiviral and antitumor immunity. Small molecules capable of triggering STING-dependent cellular processes are effective at blocking virus replication, enhancing vaccine efficacy, and facilitating immune response to cancer cells.

STING Related Products (8):

Cat. No. Product Name Effect Purity
  • HY-12885B
    ML RR-S2 CDA ammonium salt Activator 99.23%
    ML RR-S2 CDA ammonium salt is an activator of stimulator of interferon genes (STING).
  • HY-100941
    CCCP Inhibitor 99.83%
    CCCP is an oxidative phosphorylation uncoupler.
  • HY-10964
    DMXAA Agonist 99.81%
    DMXAA, the vascular disrupting agent, is a murine agonist of the stimulator of interferon genes (STING) and also a potent inducer of type I IFNs and other cytokines.
  • HY-19711
    STING agonist-1 Agonist 99.06%
    STING agonist-1 (G10) is a novel human-specific STING agonist that elicits antiviral activity against emerging Alphaviruses. G10 potently blocks replication of Alphavirus species Venezuelan Equine Encephalitis Virus (VEEV) (IC90 = 24.57 μM).
  • HY-12885
    ML RR-S2 CDA Activator 99.23%
    ML RR-S2 CDA (STING-Inducer-1) is a highly active cyclic-di-nucleotide immune stimulators that activate DCs via the cytoplamtic receptor STING (Stimulator of Interferon Genes).
  • HY-112921
    diABZI STING agonist-1 Agonist
    diABZI STING agonist-1 is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively.
  • HY-107780
    Cyclic-di-GMP Agonist 99.26%
    Cyclic-di-GMP is a STING agonist and a ubiquitous second messenger that regulates biofilm formation, motility, and virulence in diverse bacterial species.
  • HY-12512
    cGAMP Activator 98.56%
    cGAMP(Cyclic GMP-AMP) is an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA; STING ligand.
Isoform Specific Products

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.