2. Signaling Pathways
  3. Immunology/Inflammation
  4. STING
  5. STING Antagonist

STING Antagonist

STING Antagonists (6):

Cat. No. Product Name Effect Purity
  • HY-112693
    H-151
    		Antagonist 99.86%
    H-151 is a potent, selective and covalent antagonist of STING that has noteworthy inhibitory activity both in cells and in vivo. H-151 reduces TBK1 phosphorylation and suppresses STING palmitoylation. H-151 can be used for the research of autoinflammatory disease.
  • HY-162664
    STING antagonist-1
    		Antagonist 99.88%
    STING antagonist-1 is an antagonist of STING with an IC50 of 3.8 nM. STING antagonist-1 can be used in the research of autoimmune diseases, inflammatory diseases, and others.
  • HY-148644
    STING antagonist-2
    		Antagonist 99.73%
    STING antagonist-2 (Compound 50) is a potent STING antagonist with a pIC50 of 8.9. STING antagonist-2 has the potential for immunity research.
  • HY-103665A
    STING agonist-3 trihydrochloride
    		Antagonist
    STING agonist-3 trihydrochloride, extracted from patent WO2017175147A1 (example 10), is a selective and non-nucleotide small-molecule STING agonist with a pEC50 and pEC50 of 7.5 and 9.5, respectively. STING agonist-3 trihydrochloride has durable anti-tumor effect and tremendous potential to improve treatment of cancer.
  • HY-185379
    STING antagonist-3
    		Antagonist
    STING antagonist-3 is a potent STING antagonist with an IC50 of 2.3 nM against human wild-type STING. STING antagonist-3 inhibits human wild-type STING and the gain-of-function STING mutants N154S and V155M. STING antagonist-3 suppresses IFN‑α2a production in stimulated human whole blood. STING antagonist-3 inhibits IP-10 production in activated human dermal microvascular endothelial cells (HMVEC-d). STING antagonist-3 can be used for the research of autoimmune diseases, autoinflammatory diseases, interferonopathies, and fibrotic disorders.
  • HY-180120
    UM-203
    		Antagonist
    UM-203 is a reversible covalent STING antagonist. UM-203 is effective against both mouse and human STING, and in particular, it inhibits the most common human STING R232 variant. UM-203 can inhibit STING oligomerization and reduce phosphorylation of downstream TBK1 and IRF3, thereby blocking the IRF3 and NF-κB-mediated signaling pathways and inhibiting IFNβ and IL-6 secretion. UM-203 can be used for the research of inflammation and immunology, such as systemic lupus erythematosus.