3106554-00-8
Chemical Structure
STING antagonist-3
- CAS No.: 3106554-00-8
- Formula:C35H39N5O3
- Molecular Weight:577.72
InChIKey: BTZTZMDCUCKMSJ-BAMJFLLESA-N
SMILES: CC(N=C([C@@H]1CC[C@H](CC1)C(O)=O)C=C2)=C2N3C(C)=C(C(C)C)C(C4=CC=CC5=NN(C[C@H](O)C6=CC=CC=C6)C=C54)=N3
Biological Activity: STING antagonist-3 is a potent STING antagonist with an IC50 of 2.3 nM against human wild-type STING. STING antagonist-3 inhibits human wild-type STING and the gain-of-function STING mutants N154S and V155M. STING antagonist-3 suppresses IFN‑α2a production in stimulated human whole blood. STING antagonist-3 inhibits IP-10 production in activated human dermal microvascular endothelial cells (HMVEC-d). STING antagonist-3 can be used for the research of autoimmune diseases, autoinflammatory diseases, interferonopathies, and fibrotic disorders[1].
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STING antagonist-3 | STING antagonist-3 is a potent STING antagonist with an IC50 of 2.3 nM against human wild-type STING. STING antagonist-3 inhibits human wild-type STING and the gain-of-function STING mutants N154S and V155M. STING antagonist-3 suppresses IFN‑α2a production in stimulated human whole blood. STING antagonist-3 inhibits IP-10 production in activated human dermal microvascular endothelial cells (HMVEC-d). STING antagonist-3 can be used for the research of autoimmune diseases, autoinflammatory diseases, interferonopathies, and fibrotic disorders. | |||||||||||||||||||||
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Keywords
