Explore conserved antiviral mechanisms across mammals and bacteria, from virus recognition and immune signaling to metabolic defense and gasdermin-mediated cell death, and their implications for innate immune evolution.
Scientific Reviews
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Explore how mitochondrial quality control, inflammatory signaling, and metabolic–epigenetic reprogramming regulate cellular senescence and the SASP, along with strategies to restore mitochondrial homeostasis. -
Explore the mechanisms of tumor immune evasion, dynamic checkpoint regulation, and the evolution of mechanism-driven combinations and patient stratification. -
Review the biological basis of PCSK9, key therapeutic modalities, cardiovascular evidence, and future directions, including insights from the CORALreef clinical program. -
Explore advances in mRNA molecular design and targeted delivery, emerging non-LNP platforms, and key translational challenges shaping broader applications beyond vaccines. -
Obesity substantially increases the risk of chronic diseases such as T2D and cardiovascular disease. The breakout success of GLP-1 therapies has spotlighted GLP-1R and a wave of emerging obesity targets. -
Explore how anti-Aβ therapy is reshaping the AD treatment landscape, the rationale for multi-pathology combination strategies, and advances in biomarker-guided precision treatment. -
Explore the rise of TOP1i-class payloads, the impact of payload–linker design on therapeutic window and developability, and how novel payloads are expanding ADC design boundaries. -
Review the evolution of molecular glues from serendipitous discovery to rational design, highlighting how emerging targets and advances in screening, proteomics, structural biology, and AI are expanding the druggable proteome. -
Explore the mechanisms driving immune tolerance breakdown in autoimmune diseases and emerging tolerance-restoring strategies, with a focus on IL-2-based immune modulation.