1. Metabolic Enzyme/Protease
  2. DGAT

DGAT

DGAT (acyl-CoA: diacylglycerol acyltransferase) is a transmembrane enzyme that acts in the final and committed step of triacylglycerides (TAGs) synthesis, and it has been proposed to be the rate-limiting enzyme in plant storage lipid accumulation. DGAT catalyzes the acylation of sn-1,2-diacylglycerol (DAG) at the sn-3 position using an acyl-CoA substrate. DGAT has been proposed to be the rate-limiting enzyme in plant storage lipid accumulation. DGAT is considered a key enzyme for biotechnological purposes; it might be utilized to increase oil content in oleaginous plant species.

DGAT1 and DGAT2 are two of the enzymes that are responsible for the main part of TAG synthesis in most organisms, and they have been studied in many eukaryotic organisms.

DGAT Related Products (9):

Cat. No. Product Name Effect Purity
  • HY-16278
    LCQ-908 Inhibitor
    LCQ-908 is a new generation of diacylglycerol acyltransferase 1 (DGAT1) inhibitor as anti-obesity and anti-diabetic agents.
  • HY-32219
    T863 Inhibitor 99.08%
    T-863(DGAT-1 inhibitor) is an orally active, selective and potent DGAT1 (Acyl-CoA:diacylglycerol acyltransferase 1) inhibitor that interacts with the acyl-CoA binding site of DGAT1, and inhibits triacylglycerol synthesis in cells.
  • HY-10038
    A 922500 Inhibitor
    A 922500 is a potent, selective, and orally bioavailable DGAT-1 inhibitor with IC50 values of 7 nM and 24 nM for human and mouse DGAT-1 respectively.
  • HY-13009
    PF-04620110 Inhibitor 99.55%
    PF-04620110 is an orally active, selective and potent diglyceride acyltransferase-1 (DGAT1) inhibitor with IC50 of 19 nM.
  • HY-15497
    AZD7687 Inhibitor 99.60%
    AZD7687 is a potent and selective DGAT1 inhibitor with an IC50 value of 80 nM (hDGAT1).
  • HY-50670
    DGAT-1 inhibitor 2 Inhibitor
    DGAT-1 inhibitor 2 is an effective inhibitor of DGAT-1;antiobesity agents.
  • HY-N1067
    Xanthohumol Inhibitor 99.68%
    Xanthohumol is one of the principal flavonoids isolated from hops, the inhibitor of diacylglycerol acetyltransferase (DGAT), COX-1 and COX-2, and shows anti-cancer and anti-angiogenic activities.
  • HY-12425
    DGAT1-IN-1 Inhibitor 99.83%
    DGAT1-IN-1 is a potent DGAT1 inhibitor with IC50 of < 10 nM(cell lysate from Hep3B cells overexpressing human DGAT1).
  • HY-15197
    ABT-046 Inhibitor
    ABT-046 is a potent, selective, and orally bioavailable Diacylglycerol acyltransferase 1 (DGAT-1 ) inhibitor (IC50= 8 nM).