2. Induced Disease Models Products Metabolic Enzyme/Protease
  3. Immunology and Inflammatory Disease Models Acyltransferase
  4. Hapten
  5. Fumonisin B1

Fumonisin B1 is a mycotoxin produced from Fusarium moniliforme. Fumonisin B1 is a potent inhibitor of sphingosine N-acyltransferase (ceramide synthase) and disrupts de novo sphingolipid biosynthesis. Fumonisin B1 is the most abundant and toxic fumonisin.

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CAS No. : 116355-83-0

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Customer Review

Based on 9 publication(s) in Google Scholar

Other Forms of Fumonisin B1:

Fumonisin B1 Related Antibodies

Top Publications Citing Use of Products

    Fumonisin B1 purchased from MedChemExpress. Usage Cited in: Toxins. 2025 Aug 15;17(8):413.  [Abstract]

    Fumonisin B1 (FB1) (10 µM; 24 h) caused a large decrease in the d18:1/d18:0 ratio in HepG2 cells.

    Fumonisin B1 purchased from MedChemExpress. Usage Cited in: Toxins. 2025 Aug 15;17(8):413.  [Abstract]

    Fumonisin B1 (FB1) (10 µM; 24 h) caused N-acyl-AOD to no longer be detected in HepG2 or Caco-2 cells.

    Fumonisin B1 purchased from MedChemExpress. Usage Cited in: J Hazard Mater. 2024 Aug 22:478:135580.  [Abstract]

    Fumonisin B1 (3 μM, 1 h), an inhibitor of ceramide synthase, effectively diminished NaAsO2-induced increases in ceramide synthesis and exosome formation in N9 cells.

    Fumonisin B1 purchased from MedChemExpress. Usage Cited in: J Transl Med. 2023 Feb 6;21(1):89.  [Abstract]

    The ceramide synthetase inhibitor Fumonisin B1 (10 μM; 16 h) reduced the phosphorylation of PERK and the level of CC3 in PA-treated MIN6 cells.

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    ACAT1 ACAT2 MGAT2 ACAT DGAT1 DGAT2

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Fumonisin B1 is a mycotoxin produced from Fusarium moniliforme. Fumonisin B1 is a potent inhibitor of sphingosine N-acyltransferase (ceramide synthase) and disrupts de novo sphingolipid biosynthesis. Fumonisin B1 is the most abundant and toxic fumonisin[1][2].

    IC50 & Target

    Sphingosine N-acyltransferase[2]
    In Vitro

    Fumonisin B1 alters the gene expression and signal transduction pathways in monkey kidney cells[3].
    Fumonisin B1 increases the initial disruption of sphingolipid metabolism and the accumulation of sphinganine in LLC-PK1 kidney cells, causes DNA damage of apoptotic type in rat astrocytes[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Fumonisin B1 Related Antibodies
    Molecular Weight

    721.83

    Formula

    C34H59NO15
    CAS No.
    Appearance

    Solid

    Color

    White to light yellow

    SMILES

    OC(C[C@@H](C(O)=O)CC(O[C@@H](C[C@@H](C)C[C@H](O)CCCC[C@@H](O)C[C@H](O)[C@@H](N)C)[C@@H]([C@H](C)CCCC)OC(C[C@H](C(O)=O)CC(O)=O)=O)=O)=O
    Structure Classification
    Initial Source

    a toxic metabolite of Fusarium moniliforme.
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    -20°C, stored under nitrogen

    *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

    Solvent & Solubility
    In Vitro: 

    DMSO : 50 mg/mL (69.27 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    H2O : 16.67 mg/mL (23.09 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.3854 mL 6.9268 mL 13.8537 mL
    5 mM 0.2771 mL 1.3854 mL 2.7707 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

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    Volume (start)

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    V2

    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.5 mg/mL (3.46 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% Corn Oil

      Solubility: ≥ 2.5 mg/mL (3.46 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 18.5 mg/mL (25.63 mM); Clear solution; Need ultrasonic and warming

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.96%

    SDS (644 KB)

    COA (250 KB) HNMR (295 KB) RP-HPLC (241 KB) MS (98 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O / DMSO 1 mM 1.3854 mL 6.9268 mL 13.8537 mL 34.6342 mL
    5 mM 0.2771 mL 1.3854 mL 2.7707 mL 6.9268 mL
    10 mM 0.1385 mL 0.6927 mL 1.3854 mL 3.4634 mL
    15 mM 0.0924 mL 0.4618 mL 0.9236 mL 2.3089 mL
    20 mM 0.0693 mL 0.3463 mL 0.6927 mL 1.7317 mL
    DMSO 25 mM 0.0554 mL 0.2771 mL 0.5541 mL 1.3854 mL
    30 mM 0.0462 mL 0.2309 mL 0.4618 mL 1.1545 mL
    40 mM 0.0346 mL 0.1732 mL 0.3463 mL 0.8659 mL
    50 mM 0.0277 mL 0.1385 mL 0.2771 mL 0.6927 mL
    60 mM 0.0231 mL 0.1154 mL 0.2309 mL 0.5772 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Fumonisin B1 Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Fumonisin B1116355-83-0Fumonisin B 1Fumonisin B-1AcyltransferaseDiacylglycerol acyltransferaseDiglyceride acyltransferaseacyl-CoA:cholesterol acyltransferasemono- acylglycerol acyltransferaseInhibitorinhibitorinhibit

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