Flavonoids Library

96 Cited Publications
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Based on 96 publication(s) in Google Scholar

Flavonoids are an important class of natural products; particularly, they belong to a class of plant secondary metabolites having a polyphenolic structure, widely found in fruits, vegetables and certain beverages. Flavonoids can be subdivided into different subgroups depending on the carbon of the C ring on which the B ring is attached and the degree of unsaturation and oxidation of the C ring. These subgroups are: flavones, flavonols, flavanones, flavanonols, flavanols or catechins, anthocyanins and chalcones. Flavonoids are now considered as an indispensable component in a variety of nutraceutical, pharmaceutical, medicinal and cosmetic applications. This is attributed to their anti-oxidative, anti-inflammatory, anti-mutagenic and anti-carcinogenic properties coupled with their capacity to modulate key cellular enzyme function. Naturally occurring flavonoids are known to have biological activities for use as drugs, for example, in diseases like cancer, Alzheimer’s disease (AD), atherosclerosis, etc.

MCE offers a unique collection of 582 natural flavonoid compounds which is a useful tool for drug discovery as an important source of lead compounds.

For pre-dissolved solutions, 10 mM for compounds with the solubility not lower than 10 mM, 2 mM for compounds with solubility between 2 mM and 10 mM, and 3 mg/mL for compounds with unconfirmed molecular weight and solubility not lower than 3 mg/mL.

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Service

Description & Advantages

•   A unique collection of 582 natural products for high throughput screening (HTS) and high content screening (HCS).

•   The compounds in the library contain flavones, flavonols, flavanones, flavanonols, flavanols, etc.

•   A useful tool for drug discovery as an important source of lead compounds.

•   Bioactivity and safety confirmed by preclinical research and clinical trials. Some compounds have been approved by FDA.

•   Structurally diverse, bioactive, and cell permeable.

•   More detailed compound information with structure, IC50, and brief introduction.

•   NMR and HPLC validated ensure high purity.

•   All compounds are in stock and continuously updated.

Product Details

Formulation

A collection of 582 flavonoids supplied as pre-dissolved Solutions or Solid

Solution: 576 compounds supplied in 10 mM solution, 3 compounds supplied in 2 mM solution, 3 compounds supplied in 3 mg/mL solution.

Layout

96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates.
This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.

Container

96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode

Storage
-80°C
Shipping
Blue ice or dry ice

Documentation

  • PDF
  • Excel
  • SDF
  • Manual

Composition

Apoptosis (143)

Autophagy (64)

NF-κB (64)

Bacterial (57)

p38 MAPK (36)

Akt (33)

ERK (29)

Caspase (26)

COX (25)

Fungal (24)

PI3K (24)

JNK (20)

Keap1-Nrf2 (19)

MMP (15)

Parasite (15)

STAT (15)

PPAR (14)

AMPK (13)

Tyrosinase (12)

mTOR (9)

PARP (9)

SOD (9)

HIV (8)

GLUT (7)

PERK (7)

SARS-CoV (7)

CDK (6)

EGFR (6)

HSV (6)

Wnt (6)

JAK (5)

MDM-2/p53 (5)

PKC (5)

CMV (4)

SGLT (4)

Sirtuin (4)

FXR (3)

HDAC (3)

Mitophagy (3)

PKA (3)

VEGFR (3)

Amylases (2)

c-Myc (2)

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