1. Recombinant Proteins
  2. Cytokines and Growth Factors
  3. Chemokine & Receptors

Chemokines (or chemotactic cytokines, chemoattractant cytokines) are a large family of small, highly conserved cytokines (8 to 12 kDa) with chemotactic activity. Chemokines mediate the migratory patterns and positioning of all immune cells and are critical for the function of the innate immune system. They are usually categorized into four main subfamilies according to the location of N-terminal cysteine residues: CC, CXC, CX3C and C. Chemokine signals are transduced through binding to G protein-coupled receptor (GPCR) superfamily. Chemokines receptors are divided into four families based on the binding-chemokine type: receptors for CC (CCR), CXC (CXCR), C (XCR1), and for CX3C (CX3CR1). The chemokine signaling network is composed of approximately 50 secreted ligands and 20 GPCRs. Research has shown that this complex system is involved in a variety of physiological processes including mediation of cellular migration during immune responses.

Cat. No. Product Name / Synonyms Species Source
  • HY-P7282
    RANTES/CCL5 Protein, Human (HEK293)

    rHuRANTES/CCL5; C-C motif chemokine 5; SCYA5

    Human HEK293
    RANTES/CCL5 Protein, Human (HEK293) is a key pro-inflammatory chemokine in the CC chemokine family that interacts with CCR1, CCR3, CCR4, and CCR5 to mediate inflammatory immune responses, viral infections, and tumorigenesis. RANTES/CCL5 Protein, Human ( HEK293) is a recombinant human RANTES/CCL5(S24-S91) protein expressed by HEK293.
  • HY-P72786
    MPIF-1/CCL23 Protein, Human (99a.a)

    C-C motif chemokine 23; CCL23; CKB-8; MIP-3; MPIF-1; SCYA23

    Human E. coli
    MPIF-1/CCL23 protein, Human (99a.a), a CC chemokine, is highly chemotactic for resting T cells and monocytes, mediates inflammatory and immune responses by binding to the chemokine receptor CCR1, inhibits myeloid progenitor cell formation, and has some pro-cancer effects. MPIF-1/CCL23 Protein, Human (99a.a) is a recombinant human MPIF-1/CCL23 (R22-N120) protein expressed by E. coli.
  • HY-P72782
    SDF-1 beta/CXCL12 Protein, Mouse

    C-X-C motif chemokine 12; Stromal cell-derived factor 1; CXCL12; SDF-1β

    Mouse E. coli
    SDF-1 beta (Stromal-derived factor-1β, SDF-1β) is a stromal derived CXC chemokine that signal through the CXCR4 receptor. SDF-1β has chemotactic activity on B and T cells. SDF-1 beta/CXCL12 Protein, Mouse is produced in E. coli, and consists of 72 amino acids (K22-M93).
  • HY-P7281
    PF-4/CXCL4 Protein, Human (HEK293)

    rHuPF-4/CXCL4; C-X-C motif chemokine 4; Oncostatin A; SCYB4

    Human HEK293
    PF-4/CXCL4 is a member of the CXC chemokine family that is released from the alpha-granules of activated platelets. PF-4/CXCL4 binds with high affinity to heparin, with antiheparin, antiangiogenic and immunomodulatory activities. PF-4/CXCL4 plays a role in hematopoiesis and immune cell modulation. PF-4/CXCL4 Protein, Human (HEK293) is produced in HEK293 cells, and consists of 70 amino acids (E32-S101).
  • HY-P78173
    MCP-1/CCL2 Protein, Human (Biotinylated, HEK293, His-Avi)

    C-C motif chemokine 2; CCL2; HC11; MCAF; MCP-1; HSMCR30; MCP1; SCYA2; SMC-CF; GDCF-2

    Human HEK293
    MCP-1/CCL2 Protein, Human (Biotinylated, HEK293, His-Avi) is a cytokine belonging to the CC chemokine family that interacts with the CCR2 chemokine receptor on the cell surface to mediate inflammatory immune responses, viral infections, and tumorigenesis. MCP-1/CCL2 Protein MCP-1/CCL2 Protein, Human (Biotinylated, HEK293, His-Avi) is a biotinylated recombinant human MCP-1/CCL2 (Q24-T99) expressed by HEK293 with His and Avi tags at the C-terminus.
  • HY-P73411
    SDF-1 beta/CXCL12 Protein, Human (HEK293, Fc)

    Stromal Cell-Derived Factor 1; SDF-1; IRH; hIRH; PBSF; CXCL12; SDF1

    Human HEK293
    SDF-1 beta (Stromal-derived factor-1β, SDF-1β) is a stromal derived CXC chemokine that signal through the CXCR4 receptor. SDF-1β has chemotactic activity on B and T cells. SDF-1 beta/CXCL12 Protein, Human (HEK293, Fc) is produced in HEK293 cells with a N-Terminal Fc-tag. It consists of 72 amino acids (K22-M93).
  • HY-P700043AF
    Animal-Free SDF-1 alpha/CXCL12 Protein, Human (His)

    Stromal Cell-Derived Factor 1; SDF-1; IRH; hIRH; PBSF; CXCL12; SDF1

    Human E. coli
    The SDF-1 alpha/CXCL12 protein is a chemoattractant for immune cells. Animal-Free SDF-1 Beta/CXCL12 Protein, Human (His) is the recombinant human-derived animal-FreeSDF-1 Beta/CXCL12 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free SDF-1 Beta/CXCL12 Protein, Human (His) is 65 a.a., with molecular weight of ~8.55 kDa.
  • HY-P7228
    I-TAC/CXCL11 Protein, Human (HEK293)

    rHuI-TAC/CXCL11; C-X-C motif chemokine 11; Beta-R1; H174; IP-9; SCYB11

    Human HEK293
    CXCL11, also known as IFN-inducible T-cell α-chemoattractant (I-TAC), belongs to the ELR-negative CXC chemokine family. CXCL11 is produced by a variety of cells including leukocytes, fibroblasts, and endothelial cells upon stimulation with interferons (IFNs). CXCL11 signals through CXCR3. CXCL11 is associated with pleiotropic functions including chemotactic migration, regulation of cell proliferation and self-renewal, increasing cell adhesion, and modulation of angiostatic effects. I-TAC/CXCL11 Protein, Human (HEK293) consists of 73 amino acids (F22-F94) and is expressed in HEK293 cells.
  • HY-P7235
    MCP-1/CCL2 Protein, Mouse (HEK293)

    rMuMCP-1/CCL2; C-C motif chemokine 2; MCAF; MCP-1; SCYA2

    Mouse HEK293
    MCP-1/CCL2 Protein, Mouse (HEK293) is a cytokine belonging to the CC chemokine family that interacts with the CCR2 chemokine receptor on the cell surface to mediate inflammatory immune responses, viral infections, and tumorigenesis. MCP-1/CCL2 Protein, Mouse (HEK293) is a mouse MCP-1/CCL2 (Q24-R96) expressed by HEK293.
  • HY-P7237
    MCP-1/CCL2 Protein, Human

    rHuMCP-1/CCL2; C-C motif chemokine 2; MCAF; MCP-1; SCYA2

    Human E. coli
    MCP-1/CCL2 Protein, Human is a cytokine belonging to the CC chemokine family that interacts with the CCR2 chemokine receptor on the cell surface to mediate inflammatory immune responses, viral infections, and tumorigenesis. MCP-1/CCL2 Protein MCP-1/CCL2 Protein, Human is a recombinant human MCP-1/CCL2(Q24-T99) expressed by E.coil.
  • HY-P7379
    IL-8/CXCL8 Protein, Human (CHO)

    rHuIL-8/CXCL8; C-X-C motif chemokine 8; NAP-1; IL8; GCP-1

    Human CHO
    Interleukin-8 (IL-8), also known as CXCL8 or NAP-1, is a pro-inflammatory CXC chemokine. IL-8 acts on human neutrophils via two receptors, CXCR1 and CXCR2. IL-8 has a conserved Glu-Leu-Arg (ELR) N-terminal motif, and is an agonist for CXCR1/CXCR2. IL-8 is produced by various cells including leukocytes, endothelial cells, and epithelial cells. IL-8/CXCL8 Protein, Human (CHO) is produced in CHO cells, and consists of 77 amino acids (A23-S99).
  • HY-P70450
    RANTES/CCL5 Protein, Human

    C-C Motif Chemokine 5; EoCP; Eosinophil Chemotactic Cytokine; SIS-Delta; Small-Inducible Cytokine A5; T Cell-Specific Protein P228; TCP228; T-Cell-Specific Protein RANTES; CCL5; D17S136E; SCYA5

    Human E. coli
    CCL5 Protein, Human is a key pro-inflammatory chemokine in the CC chemokine family that interacts with CCR1, CCR3, CCR4, and CCR5 to mediate inflammatory immune responses, viral infections, and tumorigenesis.CCL5 Protein, Human is a recombinant human CCL5(S24-S91) protein expressed by E. coli.
  • HY-P7355
    Fractalkine/CX3CL1 Protein, Human (CHO)

    rHuFractalkine/CX3CL1; Fractalkine; CX3CL1; FKN; SCYD1; Neurotactin; NTT

    Human CHO
    Fractalkine/CX3CL1 Protein, Human (CHO) is the member of CX3C chemokine family, associated with many cancers and promotes tumor progression.
  • HY-P7287
    SDF-1 beta/CXCL12 Protein, Human (72a.a)

    rHuSDF-1β/CXCL12; C-X-C motif chemokine 12; PBSF

    Human E. coli
    SDF-1 beta (Stromal-derived factor-1β, SDF-1β) is a stromal derived CXC chemokine that signal through the CXCR4 receptor. SDF-1β has chemotactic activity on B and T cells. SDF-1 beta/CXCL12 Protein, Human (72a.a) is produced in E. coli, and consists of 72 amino acids (K22-M93).
  • HY-P7157
    ENA-78/CXCL5 Protein, Human (HEK293)

    rHuENA-78/CXCL5; ENA78; SCYB5

    Human HEK293
    CXCL5, also known as neutrophil activating peptide 78 (ENA‐78), is a CXC chemokine containing ELR motif. CXCL5 promotes angiogenesis through interaction with its specific receptor CXCR2. CXCL5 is expressed by many immune cells, such as macrophages, eosinophils, and non-immune cells including mesothelial cells, and fibroblasts.CXCL5/CXCR2 axis not only contributes to the recruitment of neutrophils but also regulates the function of neutrophils in melanoma. ENA-78/CXCL5 Protein, Human (HEK293) is produced in HEK293 cells, and consists of 78 amino acids (A37-N114).
  • HY-P7257
    CCL4 Protein, Human

    rHuMIP-1β/CCL4; C-C motif chemokine 4; LAG-1; Macrophage inflammatory protein 1-beta; SCYA4

    Human E. coli
    CCL4 Protein, Human is a small cytokine of the CC chemokine subfamily that binds to the CCR5 chemokine receptor on the cell surface, promotes leukocyte aggregation under various inflammatory conditions, and contributes to immune protection against human immunodeficiency virus type 1. CCL4 Protein, Human is a recombinant human CCL4 (A24-N92) expressed by E. coli.
  • HY-P72961
    CXCL16 Protein, Human (HEK293, His)

    C-X-C motif chemokine 16; SR-PSOX; Srpsox; SCYB16; CXCL16

    Human HEK293
    CXCL16, also known as SR-PSOX (scavenger receptor that binds phosphatidylserine and oxidized lipoprotein), is one member of the ELR-negative CXC chemokine subfamily. CXCL16 is a multifunctional protein involved in various inflammatory diseases, atherosclerosis, and cancer. CXCL16 can be observed in many cell types. CXCL16 Protein, Human (HEK293, His) is produced in HEK293 cells with a C-Terminal His-tag. It consists of 224 amino acids (M1-T224).
  • HY-P71890
    RANTES/CCL5 Protein, Mouse

    Ccl5; Scya5C-C motif chemokine 5; MuRantes; SIS-delta; Small-inducible cytokine A5; T-cell-specific protein RANTES

    Mouse E. coli
    RANTES/CCL5 Protein, Mouse is a key pro-inflammatory chemokine in the CC chemokine family that interacts with CCR1, CCR3, CCR4, and CCR5 to mediate inflammatory immune responses, viral infections, and tumorigenesis. RANTES/CCL5 Protein, Mouse is a recombinant mouse CCL5(S24-S91) protein expressed by E. coli.
  • HY-P7186
    GRO-alpha/CXCL1 Protein, Mouse (CHO)

    rMuGRO-α/CXCL1; Growth-regulated alpha protein; C-X-C motif chemokine 1; KC; HSF

    Mouse CHO
    CXCL1 (Chemokine (C-X-C motif) ligand 1), also known as GRO alpha, NAP-3 or MGSA, belongs to the sub-family of CXC chemokine. CXCL1 is involved in the development of many inflammatory diseases, including the induction of angiogenesis and recruitment of neutrophils. CXCL1 is produced by many cell types, and activates CXCR2 and, at high levels, CXCR1. GRO-alpha/CXCL1 Protein, Mouse (CHO) is produced in CHO cells, and consists of 72 amino acids (A25-N96).
  • HY-P7196
    HCC-4/CCL16 Protein, Human (CHO)

    rHuHCC-4/CCL16; C-C motif chemokine 16; SCYA16

    Human CHO
    HCC-4/CCL16 Protein, Human (CHO) is a CC chemokine that specifically attracts lymphocytes, dendritic cells and monocytes, increases their adhesion and has myelosuppressive activity. HCC-4/CCL16 Protein, Human (CHO) interacts with CCR1, CCR2, CCR5 and CCR8 to mediate inflammatory and cancer responses. HCC-4/CCL16 Protein, Human (CHO) is a recombinant human HCC-4/CCL16 (Q24-Q120) expressed by CHO.
Cat. No. Product Name Effect Purity