CCR8
C-C chemokine receptor type 8 (CCR8, CDw198) is a Gαi-coupled receptor whose biology centers on two tissues: the thymus and the skin. CCR8 was originally identified as a thymus-enriched receptor with ligands CCL1 (I-309) and, as more recently defined, CCL8 and CCL18; within the thymus, CCR8 marks cortical thymocytes and supports their development. In peripheral immunity, CCR8 has emerged as a defining marker and functional mediator of tissue regulatory T cells and Th2 cells homing to skin, where keratinocyte-derived CCL1 establishes the chemotactic gradient. CCR8+ Tregs within tumors display a highly activated, effector phenotype and constitute the dominant intratumoral Treg population in many cancers, suppressing antitumor T cells and correlating with poor prognosis; preclinical depletion of CCR8+ Tregs reinvigorates antitumor immunity, making anti-CCR8 antibodies a fast-advancing immuno-oncology strategy. CCR8 additionally contributes to atopic dermatitis and asthma Th2 pathology and serves as a minor HIV co-receptor.
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CCR8 Recombinant Proteins (4)
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Inhibitors & Agonists (25)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
