2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. IDE

IDE

Insulin-degrading enzyme; Insulinase

IDE (Insulin-degrading enzyme) is a Zn2+-dependent endopeptidase with insulin-degrading activity, belonging to the peptidase M16 family. IDE regulates blood glucose homeostasis by lowering insulin levels, while also participating in peptide hormone signaling cascades by degrading a variety of other important peptides, including APP-derived peptides, IAPP, Glucagon, natriuretic peptides (ANP, BNP, CNP), Bradykinin, Kallidin, and others. Additionally, IDE plays a crucial role in clearing Aβ plaques accumulated in the brain, which may alleviate cognitive impairments and neurodegenerative diseases associated with Aβ. IDE is also involved in antigen processing, degrading MAGEA3-derived peptides to produce antigenic peptides that are presented to cytotoxic T lymphocytes, contributing to the immune response.
IDE is an important enzyme in regulating various hormone and peptide signaling pathways and plays a critical role in research related to metabolic diseases, neurodegenerative diseases, cardiovascular diseases, and immune-related diseases[1].

IDE Related Products (5):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-110197
    6bK TFA
    		Inhibitor 99.68%
    6bK TFA is a selective insulin-degrading enzyme (IDE) inhibitor with an IC50 of 50 nM. 6bK TFA binds to the distal pocket of IDE, thereby blocking substrate binding, peptide unfolding and cleavage processes, and reducing the degradation of insulin, glucagon and amylin. 6bK TFA improves oral glucose tolerance but impairs intraperitoneal glucose tolerance. 6bK TFA can be used in research related to type 2 diabetes.
    6bK TFA
  • HY-117878
    ML345
    		Inhibitor 99.37%
    ML345 is a potent and selective inhibitor of insulin-degrading enzyme (IDE) and NLRP3, with an IC50 of 188 nM against IDE. ML345 targets the Cys819 residue of IDE to inhibit IDE. ML345 selectively binds to NLRP3 in a non-covalent manner. ML345 inhibits inflammatory cytokines (IL-1β, IL-6) and exhibits potent anti-inflammatory activity. ML345 exerts a protective effect against miscarriage.
    ML345
  • HY-W157689
    IDE-IN-2
    		Inhibitor 98.04%
    IDE-IN-2 (Compound 4) is an inhibitor for insulin-degrading enzyme. IDE-IN-2 is predicted to have CYP3A4, CYP2C19, hERG, NADP+, HIF1α and histidine kinase inhibitory activities, and has potential biological activity in anti-diabetic, anti-tumor, anti-bacterial aspects, according to the in silico prediction.
    IDE-IN-2
  • HY-110197A
    6bK formate
    		Inhibitor
    6bK formate is a potent and selective insulin degrading enzyme (IDE) inhibitor with an IC50 value of 50 nM. 6bK formate increases circulating insulin in high-fat-fed mice. Acute administration of 6bK formate enhances glucose tolerance to oral glucose, notably to a greater extent in high-fat-fed mice. 6bK formate can be used for type 2 diabetes research.
    6bK formate
  • HY-143401
    Hit 1
    		Activator
    Hit 1 is an activator of ansulin degrading enzyme (IDE), with an EC50 of 5.5 μM. Hit 1 can decrease glucose-stimulating insulin secretion.
    Hit 1