1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. NADPH Oxidase

NADPH Oxidase

NOX

NADPH-oxidase (NOX) is a highly regulated dynamic complex comprising membrane and cytosolic proteins and is the major source of nonmitochondrial cellular reactive oxygen species (ROS). The ROS generated by NADPH oxidases have crucial roles in various physiological processes, including innate immunity, modulation of redox-dependent signalling cascades, and as cofactors in the production of hormones.

NOX enzymes are a family of transmembrane proteins comprising seven members (NOX1-NOX5 and DUOX1 and DUOX2), each with a specific tissue distribution and activation mechanism. They catalyze the reduction of molecular oxygen to superoxide anion, which in turn reacts quickly to generate other ROS, such as hydrogen peroxide. Although basic NOX activity is crucial for normal physiology, overshooting activity of NOX enzymes leads to disease. NADPH oxidases are increasingly recognized as interesting drug targets.

NADPH Oxidase Related Products (30):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-100965
    Diphenyleneiodonium chloride
    Inhibitor 99.39%
    Diphenyleneiodonium chloride is a NADPH oxidase (NOX) inhibitor and also functions as a TRPA1 activator with an EC50 of 1 to 3 μM. Diphenyleneiodonium chloride selectively inhibits intracellular reactive oxygen species.
    Diphenyleneiodonium chloride
  • HY-18950
    GSK2795039
    Inhibitor 99.71%
    GSK2795039 is a NADPH oxidase 2 (NOX2) inhibitor with a mean pIC50 of 6 in different cell-free assays. GSK2795039 inhibits reactive oxygen species (ROS) production and NADPH consumption. GSK2795039 reduces apoptosis.
    GSK2795039
  • HY-12298
    Setanaxib
    Inhibitor 99.45%
    Setanaxib (GKT137831) is a selective NADPH oxidase (NOX1/4) inhibitor with Kis of 140 and 110 nM, respectively.
    Setanaxib
  • HY-N0088
    Apocynin
    Inhibitor 99.96%
    Apocynin is a selective NADPH-oxidase inhibitor with an IC50 of 10 μM. Apocynin improves acute lung inflammation in Carrageenan (HY-125474)-induced pleurisy mice model. Apocynin can also be used for cancer research. Apocynin reverses the aging process in mesenchymal stem cells to promote osteogenesis and increases bone mass.
    Apocynin
  • HY-100111
    GLX351322
    Inhibitor 99.67%
    GLX351322 is an inhibitor of NADPH oxidase 4 (Nox4), and inhibits hydrogen peroxide production from NOX4-overexpressing cells with an IC50 of 5 μM.
    GLX351322
  • HY-160524
    NOX2-IN-3
    Inhibitor
    NOX2-IN-3 (compound 3) is an inhibitor of NOX2 (NADPH Oxidase 2). NOX2-IN-3 sensitizes tumor cells to MRTX1133 (HY-134813).
    NOX2-IN-3
  • HY-12804
    VAS2870
    Inhibitor 98.45%
    VAS2870 is a NADPH oxidase (NOX) inhibitor.
    VAS2870
  • HY-12805
    ML171
    Inhibitor 99.82%
    ML171 (2-Acetylphenothiazine;2-APT) is a potent and selective NADPH oxidase 1 (Nox1) inhibitor that blocks Nox1-dependent ROS generation, with an IC50 of 0.25 μM in HEK293-Nox1 confirmatory assay.
    ML171
  • HY-101499
    GKT136901
    Inhibitor 99.61%
    GKT136901 is a potent, selective and orally active inhibitor of NADPH oxidase (NOX1/4), with Kis of 160 and 165 nM, respectively. GKT136901 is also a selective and direct scavenger of peroxynitrite. GKT136901 can be used for the research of diabetic nephropathy, stroke, and neurodegeneration. GKT136901 also has anti-inflammatory activity.
    GKT136901
  • HY-120801
    APX-115
    Inhibitor 99.58%
    APX-115 (Ewha-18278) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with Ki values of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 effectively prevents kidney injury.
    APX-115
  • HY-101499A
    GKT136901 hydrochloride
    Inhibitor 99.06%
    GKT136901 hydrochloride is a potent, selective and orally active inhibitor of NADPH oxidase (NOX1/4), with Kis of 160 and 165 nM, respectively. GKT136901 hydrochloride is also a selective and direct scavenger of peroxynitrite. GKT136901 hydrochloride can be used for the research of diabetic nephropathy, stroke, and neurodegeneration. GKT136901 hydrochloride also has anti-inflammatory activity.
    GKT136901 hydrochloride
  • HY-120801A
    APX-115 free base
    Inhibitor 98.11%
    APX-115 free base (Ewha-18278 free base) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with Ki values of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 free base effectively prevents kidney injury.
    APX-115 free base
  • HY-N3239
    Mulberrofuran G
    Inhibitor 99.84%
    Mulberrofuran G protects ischemic injury-induced cell death via inhibition of NOX4-mediated ROS generation and ER stress. Mulberrofuran G shows moderate inhibiting activity of hepatitis B virus (HBV) DNA replication with IC50 of 3.99 μM.
    Mulberrofuran G
  • HY-126195
    Fluoflavine
    Inhibitor 99.41%
    Fluoflavine (ML-090) is a selective NOX1 inhibitor with an IC50 of 90 nM. Fluoflavine has >100 selectivity for NOX1 over NOX2, NOX3, NOX4 (all IC50>10 μM). ML-090 has an IC50 of 360 nM in HEK293 cells.
    Fluoflavine
  • HY-119576
    Phox-I2
    Inhibitor 99.52%
    Phox-I2 is a selective inhibitor of p67phox-Rac1 interaction, binds to p67phox with high affinity with a Kd of ~150 nM. Phox-I2 is a NADPH oxidase 2 (NOX2) inhibitor and inhibits reactive oxygen species (ROS) production.
    Phox-I2
  • HY-P1435
    NoxA1ds
    Inhibitor
    NoxA1ds is a highly efficacious and selective Nox1 (NADPH oxidase isoform 1) inhibitor. NoxA1ds establishes a critical interaction site for Nox1-NOXA1 binding required for enzyme activation. NoxA1ds can be used for the research of hypertension, atherosclerosis and neoplasia.
    NoxA1ds
  • HY-152026
    NADPH oxidase-IN-1
    Inhibitor 99.60%
    NADPH oxidase-IN-1 is an orally active NADPH oxidase (Nox) inhibitor, related with neuronal inflammation. NADPH oxidase-IN-1 can cross the blood-brain barrier (BBB), inhibits Nox2 and Nox4 with IC50s of 1.9 μM and 2.47 μM, respectively. NADPH oxidase-IN-1 suppresses pro-inflammatory cytokines production and LPS-mediated microglial migration, also has in vivo efficacy.
    NADPH oxidase-IN-1
  • HY-111447
    VAS 3947
    Inhibitor 99.59%
    VAS 3947, a specific NADPH oxidase (NOX) inhibitor, exerts a potent antiplatelet effect. VAS3947 induces apoptosis independently of anti-NOX activity, via UPR activation, mainly due to aggregation and misfolding of proteins.
    VAS 3947
  • HY-P1435A
    NoxA1ds TFA
    Inhibitor
    NoxA1ds TFA is a potent and selective NADPH oxidase 1 (NOX1) inhibitor (IC50=20 nM). NoxA1ds TFA exhibits selectivity for NOX1 over NOX2, NOX4, NOX5 and xanthine oxidase. NoxA1ds TFA inhibits NOX1-derived O2- production in HT-29 human colon cancer cells. NoxA1ds TFA attenuates VEGF-induced human pulmonary artery endothelial cell migration under hypoxic conditions in vitro.
    NoxA1ds TFA
  • HY-W549903
    p67phox-IN-1
    Inhibitor
    p67phox-IN-1 (Formula IIIa Compound) is an inhibitor targeting the interaction between Rac GTPase and p67phox protein.
    p67phox-IN-1