Ubiquinone-1
Based on 1 Customer Validation
Ubiquinone-1 is an intermediate in the synthesis of Coenzyme Q. Ubiquinone-1 can be reduced by NADPH oxidase, hepatoma cells, Ascorbic acid (HY-B0166).
For research use only. We do not sell to patients.
- Purity : 99.0%
- CAS No.: 727-81-1
- Formula: C14H18O4
- Molecular Weight:250.29
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Storage:
Solution, -20°C, 2 years
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
Description
IC50 & Target
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Human Endogenous Metabolite |
In Vitro
Ubiquinone-1 (60 µM) induces external deamino-NADH oxidation in potato tuber mitochondria by altering the specificity of an external Rotenone (HY-B1756)-insensitive NADH dehydrogenase[1].
Ubiquinone-1 (100 µM) is rapidly and efficiently reduced to extracellularly detectable ubiquinol-1 by whole blood, isolated erythrocytes, and human hepatoma HepG2 cells[3].
Ubiquinone-1 (150 µM) is reduced by NADPH oxidase of guinea pig macrophages under anaerobic conditions[4].
Ubiquinone-1 is reduced by Ascorbic acid (HY-B0166) in a molecular oxygen concentration-controlled process[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 727-81-1
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Appearance Liquid
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Molecular Weight 250.29
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Formula C14H18O4
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Color Orange to red
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SMILES
O=C1C(OC)=C(OC)C(C(C)=C1C/C=C(C)\C)=O
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Structure Classification
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Solution, -20°C, 2 years
Protocols
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Liver Cancer Modeling
Liver cancer can be classified into primary liver cancer and secondary liver cancer. Secondary liver cancer is the metastatic liver cancer. Primary liver cancer includes hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC) and fibrolamellar HCC, of which HCC is the most common form, accounting for approximately 90% of primary liver cancers[1]. HCC mouse models include chemical agent-induced models, transplanted tumor models, and genetic engineered models.
Purity & Documentation
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Data Sheet (269 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Moller IM, et al. Ubiquinone-1 Induces External Deamino-NADH Oxidation in Potato Tuber Mitochondria. Plant Physiol. 1996 Sep;112(1):75-78. [Content Brief]
[2]. R Fato, et al. Steady-state kinetics of the reduction of coenzyme Q analogs by complex I (NADH:ubiquinone oxidoreductase) in bovine heart mitochondria and submitochondrial particles. Biochemistry. 1996 Feb 27;35(8):2705-16. [Content Brief]
[3]. Stocker R, et al. Extracellular reduction of ubiquinone-1 and -10 by human Hep G2 and blood cells. Biochim Biophys Acta. 1993 Aug 20;1158(1):15-22. [Content Brief]
[4]. Murakami M, et al. NADPH oxidase of guinea-pig macrophages catalyses the reduction of ubiquinone-1 under anaerobic conditions. Biochem J. 1986 Jul 15;237(2):541-5. [Content Brief]
[5]. Roginsky VA, et al. Reduction of ubiquinone-1 by ascorbic acid is a catalytic and reversible process controlled by the concentration of molecular oxygen. Redox Rep. 1996 Feb;2(1):55-62. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ubiquinone-1 Related Classifications
HY-113449 Related Classifications
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